ArticleLipids2010
Rapid development of fasting-induced hepatic lipidosis in the American mink (Neovison vison): effects of food deprivation and re-alimentation on body fat depots, tissue fatty acid profiles, hematology and endocrinology.
Article in Lipids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Hepatic lipidosis in nine African white-bellied pangolins (Frontiers in veterinary science · 2025Article
- Serum Analytes of American Mink (Neovison Vison) Challenged with Aleutian Mink Disease Virus.Animals : an open access journal from MDPI · 2022Article
- A Model Construction of Starvation Induces Hepatic Steatosis and Transcriptome Analysis in Zebrafish Larvae.Biology · 2021Article
- Gene expressions of de novo hepatic lipogenesis in feline hepatic lipidosis.Journal of feline medicine and surgery · 2020Article
- Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Acetylation of Cavin-1 Promotes Lipolysis in White Adipose Tissue.Molecular and cellular biology · 2017Article
- The gastrointestinal tract of farmed mink (Neovison vison) maintains a diverse mucosa-associated microbiota following a 3-day fasting period.MicrobiologyOpen · 2017Article
- Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism.Molecular and cellular biology · 2015Article
- Evidence of endoplasmic reticulum stress and liver inflammation in the American mink Neovison vison with benign hepatic steatosis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- High feeding intensity increases the severity of fatty liver in the American mink (Neovison vison) with potential ameliorating role for long-chain n-3 polyunsaturated fatty acids.Acta veterinaria Scandinavica · 2014Article
- Manifestations of fasting-induced fatty liver and rapid recovery from steatosis in voles fed lard or flaxseed oil lipids.Nutrients · 2013Article
- Peculiarities of one-carbon metabolism in the strict carnivorous cat and the role in feline hepatic lipidosis.Nutrients · 2013Review
- Article
- The effects of an abundant ectoparasite, the deer ked (Lipoptena cervi), on the health of moose (Alces alces) in Finland.Parasitology research · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic lipidosis is a common pathological finding in the American mink (Neovison vison) and can be caused by nutritional imbalance due to obesity or rapid body weight loss. The objectives of the present study were to investigate the timeline and characterize the development of hepatic lipidosis in mink in response to 0-7 days of food deprivation and liver recovery after 28 days of re-feeding. We report here the effects on hematological and endocrine variables, body fat mobilization, the development of hepatic lipidosis and the alterations in the liver lipid classes and tissue fatty acid (FA) sums. Food deprivation resulted in the rapid mobilization of body fat, most notably visceral, causing elevated hepatosomatic index and increased liver triacylglycerol content. The increased absolute amounts of liver total phospholipids and phosphatidylcholine suggested endoplasmic reticulum stress. The hepatic lipid infiltration and the altered liver lipid profiles were associated with a significantly reduced proportion of n-3 polyunsaturated FA (PUFA) in the livers and the decrease was more evident in the females. Likewise, re-feeding of the female mink resulted in a more pronounced recovery of the liver n-3 PUFA. The rapid decrease in the n-3/n-6 PUFA ratio in response to food deprivation could trigger an inflammatory response in the liver. This could be a key contributor to the pathophysiology of fatty liver disease in mink influencing disease progression.
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