ReviewDeutsches Arzteblatt international2009
Placebo: misunderstandings and prejudices.
Review in Deutsches Arzteblatt international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- The placebo effect and its clinical associations in gambling disorder.Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · 2017Pooled it
- The placebo response of injectable GLP-1 receptor agonists vs. oral DPP-4 inhibitors and SGLT-2 inhibitors: a systematic review and meta-analysis.British journal of clinical pharmacology · 2016Pooled it
- Placebo response in trichotillomania.International clinical psychopharmacology · 2017Trial
- Trial
- [Laser acupuncture for chronic back pain. A double-blind clinical study].Schmerz (Berlin, Germany) · 2010Trial
- Duration of untreated illness in gambling disorder.CNS spectrums · 2024Article
- Dilemma of prescribing aripiprazole under the Taiwan health insurance program: a descriptive study.Neuropsychiatric disease and treatment · 2015Article
- [Pain and anesthesiology : aspects of the development of modern pain therapy in the twentieth century].Der Anaesthesist · 2011Review
- Paracetamol and the placebo effect in osteoarthritis trials: a missing link?Pain research and treatment · 2011Article
- Dilemma in Jurisdiction.Deutsches Arzteblatt international · 2010Article
- Statistical methods are inadequate.Deutsches Arzteblatt international · 2010Article
- Results are easily manipulated.Deutsches Arzteblatt international · 2010Article
- Stop the trench wars.Deutsches Arzteblatt international · 2010Article
- Therapies that promote emancipation.Deutsches Arzteblatt international · 2010Article
- Professional ban.Deutsches Arzteblatt international · 2010Article
- Influence of the therapeutic environment.Deutsches Arzteblatt international · 2010Article
- Epigenetics.Deutsches Arzteblatt international · 2010Article
Corrections and comments
- Commented on by
- Commented on byEpigenetics.2010
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of placebos is often misunderstood, leading both to overvaluation and to inappropriate disdain. The effect of a placebo that contains no pharmacologically active substance is often confused with the effect of administration by a physician. The aim of this article is to review the current data on placebos, evaluate these data critically, and provide a well-founded and understandable explanation of the effects that placebos do and do not possess.
methodsSelective literature review.
resultsRecent studies employing modern imaging techniques have provided objective correlates of the effect of placebo administration for certain indications. A recent paper even suggested a genetic basis for it. Two main mechanisms underlie the effect of placebo administration: conditioned reflexes, which are subconscious, and the patient's expectations, which are conscious. Further factors include the physician's personality and the setting in which the treatment takes place.
conclusionsThe mechanisms of action of placebo administration, with which positive therapeutic effects can be achieved with little effort, should be consciously exploited by physicians when giving their patients pharmacologically active medications as well.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.