ArticlePLoS genetics2009
Fruit-surface flavonoid accumulation in tomato is controlled by a SlMYB12-regulated transcriptional network.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.
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Who cites it
118 citing papers in PubMed, 1 synthesis or guideline pooled it.
- eQTL Meta-Analysis Reveals Conserved and Population-Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Pooled it
- Cultivar-Dependent Biosynthesis, Sustainable Recovery, and Industrial Applications of Tomato-Derived Carotenoids.Plants (Basel, Switzerland) · 2026Review
- Article
- Shaping the Plant Specialized Metabolites Through Modern Breeding Technique.Molecular biotechnology · 2026Review
- Developing new tomato lines in Indigo Rose genetic background with differential anthocyanin and carotenoid production in fruits.Frontiers in plant science · 2026Article
- Integrated metabolome and transcriptome reveal the molecular basis of flavonoid pathway-mediated fruit firmness variation in sweet cherry (Current research in food science · 2026Article
- QTL pyramiding uncovers epistatic interactions that modify cuticle phenolics in tomato.Frontiers in plant science · 2026Article
- Association mapping of tomato fruit quality for weight, firmness, brix, and color using GWAS.BMC plant biology · 2025Article
- SlBES1-mediated brassinosteroid signaling suppresses flavonoid biosynthesis in tomato fruit.Plant communications · 2025Article
- Integrative analysis of the transcriptome and metabolome reveals the peel coloration mechanism of Zanthoxylum armatum.BMC plant biology · 2025Article
- Bi-functional transcription factor SlbHLH95 regulates fruits flavonoid metabolism and grey mould resistance in tomato.Plant biotechnology journal · 2025Article
- Molecular mechanisms driving the unusual pigmentation shift during eggplant fruit development.Plant communications · 2025Article
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Exploring the structural variability in developing wheat grains using autofluorescence multispectral imaging at the macroscopic scale.Frontiers in plant science · 2025Article
- Fine mapping and candidate gene analysis of qSRC3 controlling the silk color in maize (Zea mays L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Increasing flavonoid contents of tomato fruits through disruption of the SlSPL-CNR, a suppressor of SlMYB12 transcription activity.Plant biotechnology journal · 2024Article
- SlERF.G3-Like mediates a hierarchical transcriptional cascade to regulate ripening and metabolic changes in tomato fruit.Plant biotechnology journal · 2024Article
- A Biostimulant Based on Silicon Chelates Enhances Growth and Modulates Physiological Responses of In-Vitro-Derived Strawberry Plants to In Vivo Conditions.Plants (Basel, Switzerland) · 2023Article
- Beyond skin-deep: targeting the plant surface for crop improvement.Journal of experimental botany · 2023Review
- Population analysis reveals the roles of DNA methylation in tomato domestication and metabolic diversity.Science China. Life sciences · 2023Article
58 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cuticle covering plants' aerial surfaces is a unique structure that plays a key role in organ development and protection against diverse stress conditions. A detailed analysis of the tomato colorless-peel y mutant was carried out in the framework of studying the outer surface of reproductive organs. The y mutant peel lacks the yellow flavonoid pigment naringenin chalcone, which has been suggested to influence the characteristics and function of the cuticular layer. Large-scale metabolic and transcript profiling revealed broad effects on both primary and secondary metabolism, related mostly to the biosynthesis of phenylpropanoids, particularly flavonoids. These were not restricted to the fruit or to a specific stage of its development and indicated that the y mutant phenotype is due to a mutation in a regulatory gene. Indeed, expression analyses specified three R2R3-MYB-type transcription factors that were significantly down-regulated in the y mutant fruit peel. One of these, SlMYB12, was mapped to the genomic region on tomato chromosome 1 previously shown to harbor the y mutation. Identification of an additional mutant allele that co-segregates with the colorless-peel trait, specific down-regulation of SlMYB12 and rescue of the y phenotype by overexpression of SlMYB12 on the mutant background, confirmed that a lesion in this regulator underlies the y phenotype. Hence, this work provides novel insight to the study of fleshy fruit cuticular structure and paves the way for the elucidation of the regulatory network that controls flavonoid accumulation in tomato fruit cuticle.
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