ArticleInvestigative ophthalmology & visual science2010
Visual Arrestin 1 contributes to cone photoreceptor survival and light adaptation.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- End binding-3 inhibitor activates regenerative program in age-related macular degeneration.Cell reports. Medicine · 2023Article
- Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging.Frontiers in aging neuroscience · 2022Article
- BBSome Component BBS5 Is Required for Cone Photoreceptor Protein Trafficking and Outer Segment Maintenance.Investigative ophthalmology & visual science · 2020Article
- Rhythmic Regulation of Photoreceptor and RPE Genes Important for Vision and Genetically Associated With Severe Retinal Diseases.Investigative ophthalmology & visual science · 2018Article
- Electrophysiological Studies on The Dynamics of Luminance Adaptation in the Mouse Retina.Vision (Basel, Switzerland) · 2017Article
- Arrestin 1 and Cone Arrestin 4 Have Unique Roles in Visual Function in an All-Cone Mouse Retina.Investigative ophthalmology & visual science · 2015Article
- Visual Cone Arrestin 4 Contributes to Visual Function and Cone Health.Investigative ophthalmology & visual science · 2015Article
- Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.Investigative ophthalmology & visual science · 2015Article
- Development of an MRI biomarker sensitive to tetrameric visual arrestin 1 and its reduction via light-evoked translocation in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.Molecular vision · 2015Article
- Changes in the harmonic components of the flicker electroretinogram during light adaptation.Documenta ophthalmologica. Advances in ophthalmology · 2014Article
- Primate short-wavelength cones share molecular markers with rods.Advances in experimental medicine and biology · 2014Article
- Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models.Progress in retinal and eye research · 2012Review
- Redox proteomic identification of visual arrestin dimerization in photoreceptor degeneration after photic injury.Investigative ophthalmology & visual science · 2012Article
- Potential cellular functions of N-ethylmaleimide sensitive factor in the photoreceptor.Advances in experimental medicine and biology · 2012Review
- Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina.PloS one · 2012Article
- Characterization of the pituitary tumor transforming gene 1 knockout mouse retina.Neurochemical research · 2011Article
- KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.Human molecular genetics · 2011Article
- Differences in RDS trafficking, assembly and function in cones versus rods: insights from studies of C150S-RDS.Human molecular genetics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate morphologic and functional contributions of Arrestin 1 (Arr1) and Arrestin 4 (Arr4) in cone photoreceptors, the authors examined the phenotypes of visual arrestin knockout mice (Arr1(-/-), Arr4(-/-), Arr1(-/-)Arr4(-/-) [Arr-DKO]) reared in darkness.
methodsRetinal rods and cones were evaluated in wild-type (WT), Arr1(-/-), Arr4(-/-), and Arr-DKO mice using quantitative morphologic analysis, immunoblot, immunohistochemistry, TUNEL, and electroretinographic (ERG) techniques.
resultsCompared with either Arr4(-/-) or WT, Arr1(-/-) and Arr-DKO mice had increased apoptotic nuclei in their retinal outer nuclear layer (ONL) at postnatal day (P) 22. By P60, cone density was significantly diminished, but the ONL appeared normal. After 1 minute of background illumination, cone ERG b-wave amplitudes were similar in WT and all Arr KO mice. However, by 3 minutes and continuing through 15 minutes of light adaptation, the cone b-wave amplitudes of WT and Arr4(-/-) mice increased significantly over those of the Arr1(-/-) and Arr-DKO mice, which demonstrated no cone b-wave amplitude increase. In contrast, ERG flicker analysis after the 15-minute light adaptation period demonstrated no loss in amplitude for either Arr1(-/-) or Arr4(-/-) mice, whereas Arr-DKO had significantly lower amplitudes. When Arr1 expression was restored in Arr1(-/-) mice (+p48(Arr1-/-)), normal cone density and light-adapted ERG b-wave amplitudes were observed.
conclusionsIn the adult dark-reared Arr1(-/-) and Arr-DKO mice, viable cones diminish over time. Arr1 expression is essential for cone photoreceptor survival and light adaptation, whereas either Arr1 or Arr4 is necessary for maintaining normal flicker responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.