ArticleNucleic acids research2010
Cell cycle-dependent variations in protein concentration.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Walking the tightrope: Balancing opposing cooperativities in dynein assembly.The Journal of biological chemistry · 2026Article
- Walking the Tightrope: Balancing Opposing Cooperativities as an Operating Principle in Dynein Assembly.bioRxiv : the preprint server for biology · 2026Article
- Impact of variability in cell generation times on cell-to-cell variability of protein concentrations.bioRxiv : the preprint server for biology · 2026Article
- Cyclo-stationary distributions of mRNA and Protein counts for random cell division times.bioRxiv : the preprint server for biology · 2025Article
- Predictability of environment-dependent formation of G-quadruplex DNAs in human mitochondria.Communications chemistry · 2025Article
- Patterns of protein synthesis in the budding yeast cell cycle: variable or constant?Microbial cell (Graz, Austria) · 2024Article
- Determining growth rates from bright-field images of budding cells through identifying overlaps.eLife · 2023Article
- Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle.Nature metabolism · 2023Article
- TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle.Journal of cell science · 2022Article
- SystematicACS synthetic biology · 2022Article
- A convolutional neural network for segmentation of yeast cells without manual training annotations.Bioinformatics (Oxford, England) · 2022Article
- Article
- A single-cell analytical approach to quantify activated caspase-3/7 during osteoblast proliferation, differentiation, and apoptosis.Analytical and bioanalytical chemistry · 2021Article
- Interactive effects of light quality and culturing temperature on algal cell size, biomass doubling time, protein content, and carbohydrate content.Applied microbiology and biotechnology · 2021Article
- Scaling of Subcellular Structures.Annual review of cell and developmental biology · 2020Review
- Clb3-centered regulations are recurrent across distinct parameter regions in minimal autonomous cell cycle oscillator designs.NPJ systems biology and applications · 2020Article
- Differential scaling between G1 protein production and cell size dynamics promotes commitment to the cell division cycle in budding yeast.Nature cell biology · 2019Article
- Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging.Nature communications · 2019Article
- Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation.eLife · 2019Article
- Division rate, cell size and proteome allocation: impact on gene expression noise and implications for the dynamics of genetic circuits.Royal Society open science · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Computational modeling of biological systems has become an effective tool for analyzing cellular behavior and for elucidating key properties of the intricate networks that underlie experimental observations. While most modeling techniques rely heavily on the concentrations of intracellular molecules, little attention has been paid to tracking and simulating the significant volume fluctuations that occur over each cell division cycle. Here, we use fluorescence microscopy to acquire single cell volume trajectories for a large population of Saccharomyces cerevisiae cells. Using this data, we generate a comprehensive set of statistics that govern the growth and division of these cells over many generations, and we discover several interesting trends in their size, growth and protein production characteristics. We use these statistics to develop an accurate model of cell cycle volume dynamics, starting at cell birth. Finally, we demonstrate the importance of tracking volume fluctuations by combining cell division dynamics with a minimal gene expression model for a constitutively expressed fluorescent protein. The significant oscillations in the cellular concentration of a stable, highly expressed protein mimic the observed experimental trajectories and demonstrate the fundamental impact that the cell cycle has on cellular functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.