ArticleJournal of lipid research2010
Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- LPLAT7 reutilizes unsaturated 1-lysophospholipids formed during lysosomal phospholipid degradation.Journal of lipid research · 2026Article
- Identification of novel high-risk genes in gastric cancer through single-cell RNA sequencing, eQTL Mendelian randomization, and in vitro validation.Global medical genetics · 2025Article
- Biological mechanism and functional verification of key genes related to major depressive disorder and type 2 diabetes mellitus.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Phospholipid Acyltransferases: Characterization and Involvement of the Enzymes in Metabolic and Cancer Diseases.Cancers · 2024Review
- Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish.Scientific reports · 2022Article
- Aberrant expression of HDL-bound microRNA induced by a high-fat diet in a pig model: implications in the pathogenesis of dyslipidaemia.BMC cardiovascular disorders · 2021Article
- The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes.Biomolecules · 2020Article
- Genome-wide scan reveals genetic divergence and diverse adaptive selection in Chinese local cattle.BMC genomics · 2019Article
- Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis.Cellular and molecular gastroenterology and hepatology · 2019Article
- Article
- Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.Journal of lipid research · 2016Article
- Transcriptome profile of liver at different physiological stages reveals potential mode for lipid metabolism in laying hens.BMC genomics · 2015Article
- Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism.Journal of lipid research · 2015Review
- Glycerophosphate/Acylglycerophosphate acyltransferases.Biology · 2014Review
- Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance.The Journal of biological chemistry · 2014Article
- Alkyne lipids as substrates for click chemistry-based in vitro enzymatic assays.Journal of lipid research · 2013Article
- Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.Obesity (Silver Spring, Md.) · 2013Article
- Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.Journal of lipid research · 2012Article
- Dietary triacylglycerol structure and its role in infant nutrition.Advances in nutrition (Bethesda, Md.) · 2011Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acyl-CoA:monoacylglycerol acyltransferase (MGAT) plays a predominant role in the resynthesis of triacylglycerol in the small intestine, but its contribution to triacylglycerol synthesis in other tissues, such as the liver, is not clear. In this study, we identified a novel MGAT gene, which is identical with lysophosphatidylglycerol acyltransferase1 (LPGAT1). Mouse LPGAT1 is expressed in a number of tissues and most highly expressed in the liver. Hepatic LPGAT1 expression in diabetic db/db mice is higher than that in the control db/m mouse, which is consistent with increased hepatic MGAT activity in db/db mouse. To elucidate the role of LPGAT1 gene in lipid metabolism in db/db mice, we constructed an adenovirus of short hairpin RNA (shRNA) targeting LPGAT1 to selectively knockdown LPGAT1 gene expression in the liver. Hepatic MGAT activity and LPGAT1 expression in db/db mice infected with LPGAT1 shRNA adenovirus were significantly lower than those in mice infected with the control virus. Notably, treatment with LPGAT1 shRNA adenovirus caused a marked reduction in serum triacylglycerol and cholesterol levels and a significant increase in hepatic cholesterol level. These findings indicate that LPGAT1, a newly identified MGAT enzyme, plays a significant role in hepatic triacylglycerol synthesis and secretion in db/db mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.