ArticleBiology of reproduction2010
ERBB receptor feedback inhibitor 1 regulation of estrogen receptor activity is critical for uterine implantation in mice.
Article in Biology of reproduction, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Revolutionizing Implantation Studies: Uterine-Specific Models and Advanced Technologies.Biomolecules · 2025Review
- Establishment of Murine Pregnancy Requires the Promyelocytic Leukemia Zinc Finger Transcription Factor.International journal of molecular sciences · 2024Article
- Loss of MIG-6 results in endometrial progesterone resistance via ERBB2.Nature communications · 2022Article
- Spatiotemporal endometrial transcriptome analysis revealed the luminal epithelium as key player during initial maternal recognition of pregnancy in the mare.Scientific reports · 2021Article
- Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases.Cells · 2021Review
- Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus†.Biology of reproduction · 2020Article
- β-catenin activates TGF-β-induced epithelial-mesenchymal transition in adenomyosis.Experimental & molecular medicine · 2020Article
- Uterine Luminal Epithelium as the Transient Gateway for Embryo Implantation.Trends in endocrinology and metabolism: TEM · 2020Review
- Maternal Recognition of Pregnancy in the Horse: Are MicroRNAs the Secret Messengers?International journal of molecular sciences · 2020Article
- Molecular mechanisms of embryonic implantation in mammals: Lessons from the gene manipulation of mice.Reproductive medicine and biology · 2018Review
- Uterine function in the mouse requires speckle-type poz protein.Biology of reproduction · 2018Article
- MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT.BMC cancer · 2018Article
- G-protein coupled receptor 64 is required for decidualization of endometrial stromal cells.Scientific reports · 2017Article
- cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis.Current molecular medicine · 2016Article
- Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling.Biochemical and biophysical research communications · 2015Article
- Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation.Cancer research · 2014Article
- CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis.PloS one · 2014Article
- Physiological and molecular determinants of embryo implantation.Molecular aspects of medicine · 2013Review
- Critical tumor suppressor function mediated by epithelial Mig-6 in endometrial cancer.Cancer research · 2013Article
- Expression pattern implicates a potential role for luman recruitment factor in the process of implantation in uteri and development of preimplantation embryos in mice.The Journal of reproduction and development · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. E2 acts to stimulate the proliferation of uterine epithelial cells, while P4 action inhibits E2-mediated proliferation of the epithelium. P4 through its cognate receptor, the P4 receptor (Pgr), has important roles in the establishment and maintenance of pregnancy. In previous studies, we have identified ERBB receptor feedback inhibitor 1 (Errfi1) as a downstream target of Pgr action in the uterus. Herein, we show that Errfi1 mRNA expression was significantly increased in the uterus after Day 2.5 of gestation. Its expression is also induced in the uterus by acute E2 treatment, and this induction is synergistically induced by chronic E2 and P4 treatment. Although it is known that conditional ablation of Errfi1 in the Pgr-positive cells (Errfi1(d/d)) results in infertility, the function of Errfi1 in reproductive biology has remained elusive. Using Errfi1(d/d) mice, we have identified Errfi1 as an important mediator of uterine implantation. Epithelial ESR1 and target genes were significantly increased in the uteri of Errfi1(d/d) mice. Our results identify a new signaling paradigm of steroid hormone regulation in female reproductive biology that adds insight into the underlying dysregulation of hormonal signaling in human reproductive disorders such as endometriosis and endometrial cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.