ArticleJournal of experimental botany2010
Induced production of antifungal naphthoquinones in the pitchers of the carnivorous plant Nepenthes khasiana.
Article in Journal of experimental botany, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 90 citations in OpenAlex.
- Characterization of culturable endophytes and microbial communities in the rhizosphere and pitcher fluid of the carnivorous plant Nepenthes khasiana.Archives of microbiology · 2026Article
- Structure and Immunocytochemical Analysis of Tracheoid Idioblasts inInternational journal of molecular sciences · 2026Article
- Review
- External Glands ofInternational journal of molecular sciences · 2025Article
- The Occurrence, Uses, Biosynthetic Pathway, and Biotechnological Production of Plumbagin, a Potent Antitumor Naphthoquinone.Molecules (Basel, Switzerland) · 2025Review
- Distribution of Acetogenic Naphthoquinones in Droseraceae and Their Chemotaxonomic Utility.Biology · 2024Review
- Effects of chitosan on plant growth under stress conditions: similarities with plant growth promoting bacteria.Frontiers in plant science · 2024Review
- Do Reactive Oxygen and Nitrogen Species Have a Similar Effect on Digestive Processes in CarnivorousBiology · 2023Review
- Biological Potential of Carnivorous Plants from Nepenthales.Molecules (Basel, Switzerland) · 2023Review
- Carnivorous Plants from Nepenthaceae and Droseraceae as a Source of Secondary Metabolites.Molecules (Basel, Switzerland) · 2023Review
- Is the Phytotoxic Effect of Digestive Fluid ofPlants (Basel, Switzerland) · 2023Article
- ROS and RNS Alterations in the Digestive Fluid ofPlants (Basel, Switzerland) · 2022Article
- 1,4-Naphthoquinone Motif in the Synthesis of New Thiopyrano[2,3-Molecules (Basel, Switzerland) · 2022Article
- Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family.International journal of molecular sciences · 2022Review
- Plumbagin, a Potent Naphthoquinone fromMolecules (Basel, Switzerland) · 2021Article
- Plant Beneficial Features and Application of Paraburkholderia sp. NhPBG1 Isolated from Pitcher of Nepenthes hamblack.Probiotics and antimicrobial proteins · 2021Article
- UPLC-TOF-MS/MS-Based Metabolomics Analysis Reveals Species-Specific Metabolite Compositions in Pitchers ofFrontiers in plant science · 2021Article
- Phytomedicine from Middle Eastern Countries: An Alternative Remedy to Modern Medicine againstEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Carnivorous Nepenthes x ventrata plants use a naphthoquinone as phytoanticipin against herbivory.PloS one · 2021Article
- Pitchers of Nepenthes khasiana express several digestive-enzyme encoding genes, harbor mostly fungi and probably evolved through changes in the expression of leaf polarity genes.BMC plant biology · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nepenthes spp. are carnivorous plants that have developed insect capturing traps, evolved by specific modification of the leaf tips, and are able to utilize insect degradation products as nutritional precursors. A chitin-induced antifungal ability, based on the production and secretion to the trap liquid of droserone and 5-O-methyldroserone, is described here. Such specific secretion uniquely occurred when chitin injection was used as the eliciting agent and probably reflects a certain kind of defence mechanism that has been evolved for protecting the carnivory-based provision of nutritional precursors. The pitcher liquid containing droserone and 5-O-methyldroserone at 3:1 or 4:1 molar ratio, as well as the purified naphthoquinones, exerted an antifungal effect on a wide range of plant and human fungal pathogens. When tested against Candida and Aspergillus spp., the concentrations required for achieving inhibitory and fungicidal effects were significantly lower than those causing cytotoxicity in cells of the human embryonic kidney cell line, 293T. These naturally secreted 1,4-naphthoquinone derivatives, that are assumed to act via semiquinone enhancement of free radical production, may offer a new lead to develop alternative antifungal drugs with reduced selectable pressure for potentially evolved resistance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.