ArticleThe Journal of biological chemistry2010
Growth factor regulation of prostaglandin-endoperoxide synthase 2 (Ptgs2) expression in colonic mesenchymal stem cells.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Impact of gut microbiota on colorectal anastomotic healing (Review).Molecular and clinical oncology · 2025Review
- Transcriptomic Analysis Divulges Differential Expressions of Microglial Genes After Microglial Repopulation in Mice.International journal of molecular sciences · 2025Article
- Impaired functions of human monocyte-derived dendritic cells and induction of regulatory T cells by pathogenic Leptospira.PLoS neglected tropical diseases · 2023Article
- Definitive Endodermal Cells Supply an in vitro Source of Mesenchymal Stem/Stromal Cells.Communications biology · 2023Article
- Studying the potential of upregulated PTGS2 and VEGF-C besides hyper-methylation of PTGS2 promoter as biomarkers of Acute myeloid leukemia.Molecular biology reports · 2022Article
- Role of prostaglandin E2 in tissue repair and regeneration.Theranostics · 2021Review
- Hyaluronic acid promotes Lgr5American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Nonmicrobial Activation of TLRs Controls Intestinal Growth, Wound Repair, and Radioprotection.Frontiers in immunology · 2020Review
- Article
- Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration.Cell host & microbe · 2018Article
- Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium.The EMBO journal · 2017Article
- Isolation and characterization of putative mesenchymal stem cells from mammalian gut.Cytotechnology · 2016Article
- Genes related to inflammation and bone loss process in periodontitis suggested by bioinformatics methods.BMC oral health · 2015Article
- Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis.The Journal of clinical investigation · 2015Article
- Stem cells for murine interstitial cells of cajal suppress cellular immunity and colitis via prostaglandin E2 secretion.Gastroenterology · 2015Article
- Striking similarity in the gene expression levels of individual Myc module members among ESCs, EpiSCs, and partial iPSCs.PloS one · 2013Article
- Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice.Gastroenterology · 2012Article
- Article
- Colonic epithelial response to injury requires Myd88 signaling in myeloid cells.Mucosal immunology · 2012Article
- Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We previously found that a population of colonic stromal cells that constitutively express high levels of prostaglandin-endoperoxide synthase 2 (Ptgs2, also known as Cox-2) altered their location in the lamina propria in response to injury in a Myd88-dependent manner (Brown, S. L., Riehl, T. E., Walker, M. R., Geske, M. J., Doherty, J. M., Stenson, W. F., and Stappenbeck, T. S. (2007) J. Clin. Invest. 117, 258-269). At the time of this study, the identity of these cells and the mechanism by which they expressed high levels of Ptgs2 were unknown. Here we found that these colonic stromal cells were mesenchymal stem cells (MSCs). These colonic MSCs expressed high Ptgs2 levels not through interaction with bacterial products but instead as a consequence of mRNA stabilization downstream of Fgf9 (fibroblast growth factor 9), a growth factor that is constitutively expressed by the intestinal epithelium. This stabilization was mediated partially through a mechanism involving endogenous CUG-binding protein 2 (CUGbp2). These studies suggest that Fgf9 is an important factor in the regulation of Ptgs2 in colonic MSCs and may be a factor involved in its constitutive expression in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.