ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2010
Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Meloxicam protects against muscle and metabolic decline in ageing through Cdon restoration and oxidative stress modulation.Experimental & molecular medicine · 2026Article
- Sex Differences in Response to Diet Enriched With Glutathione Precursors in the Aging Heart.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis.Chembiochem : a European journal of chemical biology · 2023Article
- Resistance Training Modulates Reticulum Endoplasmic Stress, Independent of Oxidative and Inflammatory Responses, in Elderly People.Antioxidants (Basel, Switzerland) · 2022Article
- Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle.Antioxidants (Basel, Switzerland) · 2022Review
- The effect of aerobic vs. resistance training on plasma homocysteine in individuals with type 2 diabetes.Journal of diabetes and metabolic disorders · 2020Article
- Downregulated Recycling Process but Not De Novo Synthesis of Glutathione Limits Antioxidant Capacity of Erythrocytes in Hypoxia.Oxidative medicine and cellular longevity · 2020Article
- Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles.GeroScience · 2019Article
- Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology.Oxidative medicine and cellular longevity · 2018Article
- Exercise induced upregulation of glutamate-cysteine ligase catalytic subunit and glutamate-cysteine ligase modifier subunit gene expression in Thoroughbred horses.Asian-Australasian journal of animal sciences · 2017Article
- Transcriptomics analysis and hormonal changes of male and female neonatal rats treated chronically with a low dose of acrylamide in their drinking water.Toxicology reports · 2016Article
- Oxidative stress response and Nrf2 signaling in aging.Free radical biology & medicine · 2015Review
- Independent and co-morbid HIV infection and Meth use disorders on oxidative stress markers in the cerebrospinal fluid and depressive symptoms.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Article
- Altered glutamate cysteine ligase expression and activity in renal cell carcinoma.Biomedical reports · 2014Article
- Altered glutamate cysteine ligase activity in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.Experimental and therapeutic medicine · 2014Article
- Resveratrol affects the expression of glutamate cysteine ligase in the kidneys of aged rats.Experimental and therapeutic medicine · 2014Article
- Consequences of age on ischemic wound healing in rats: altered antioxidant activity and delayed wound closure.Age (Dordrecht, Netherlands) · 2014Article
- Interplay between aging and unloading on oxidative stress in fast-twitch muscles.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Restoration of glyoxalase enzyme activity precludes cognitive dysfunction in a mouse model of Alzheimer's disease.ACS chemical neuroscience · 2013Article
- NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary Restriction.Journal of clinical & experimental pathology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
This study investigated the mechanisms responsible for the disrupted homeostasis of reduced glutathione (GSH) in aging muscles with stress (14 days of hind-limb unloading [HU]). Adult and old rats were randomized into four groups: weight bearing and 3, 7, and 14 days of HU. Soleus muscles were harvested to investigate the activity or content of enzymes involved in GSH metabolism (utilization and synthesis). The activities of glutathione S transferase, glutathione reductase, gamma-glutamyl transpeptidase, and glutamate cysteine ligase (GCL) were determined. The protein content of the two subunits of GCL, catalytic subunit (GCLC) and modifier subunit (GCLM), were evaluated. The major results, failure to maintain the accelerated GCLC production and GCL activity, are associated with the GSH depletion in aging muscles with 14 days of HU. The results suggest that the regulation of GCL, especially the catalytic subunit, with stress may be compromised in aging muscles.
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Registered trials
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