ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Asymmetric dimethylarginine in angiotensin II-induced hypertension.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 50 citations in OpenAlex.
- Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase.Journal of the American Heart Association · 2016Trial
- Pregnancy-dependent cardioprotection via GPER activation in Dahl salt-sensitive rats with superimposed preeclampsia.American journal of physiology. Heart and circulatory physiology · 2025Article
- Oxidative Stress in Kidney Injury and Hypertension.Antioxidants (Basel, Switzerland) · 2024Review
- Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice.Clinical science (London, England : 1979) · 2021Article
- Blood pressure and albuminuria in a female mouse model of systemic lupus erythematosus: impact of long-term high salt consumption.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Effect of high-altitude trekking on blood pressure and on asymmetric dimethylarginine and isoprostane production: Results from a Mount Ararat expedition.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia.Biomolecules · 2020Article
- Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA) Concentrations in Patients with Obesity and the Risk of Obstructive Sleep Apnea (OSA).Journal of clinical medicine · 2019Article
- Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension.PloS one · 2019Article
- Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease.International journal of molecular sciences · 2017Review
- Pregnant rats treated with a high-fat/prooxidant Western diet with ANG II and TNF-α are resistant to elevations in blood pressure and renal oxidative stress.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Hemodynamic basis for the limited renal injury in rats with angiotensin II-induced hypertension.American journal of physiology. Renal physiology · 2015Article
- Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension.American journal of physiology. Renal physiology · 2014Article
- Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.Journal of medicinal chemistry · 2014Article
- Blood pressure-renal blood flow relationships in conscious angiotensin II- and phenylephrine-infused rats.American journal of physiology. Renal physiology · 2013Article
- Effect of resistance training on plasma nitric oxide and asymmetric dimethylarginine concentrations in type I diabetic rats.International journal of preventive medicine · 2013Article
- Renal redox response to normal pregnancy in the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Effects of voluntary wheel running on the kidney at baseline and after ischaemia-reperfusion-induced acute kidney injury: a strain difference comparison.The Journal of physiology · 2013Article
- Renal microvascular dysfunction, hypertension and CKD progression.Current opinion in nephrology and hypertension · 2013Review
- Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation.Journal of medicinal chemistry · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent studies have shown that asymmetric dimethylarginine (ADMA), a nitric oxide synthase inhibitor, is increased in hypertension and chronic kidney disease. However, little is known about the effects of hypertension per se on ADMA metabolism. The purpose of this study was to test the hypothesis that ANG II-induced hypertension, in the absence of renal injury, is associated with increased oxidative stress and plasma and renal cortex ADMA levels in rats. Male Sprague-Dawley rats were treated with ANG II at 200 ng.kg(-1).min(-1) sc (by minipump) for 1 or 3 wk or at 400 ng.kg(-1).min(-1) for 6 wk. Mean arterial pressure was increased after 3 and 6 wk of ANG II; however, renal injury (proteinuria, glomerular sclerosis, and interstitial fibrosis) was only evident after 6 wk of treatment. Plasma thiobarbituric acid reactive substances concentration and renal cortex p22(phox) protein abundance were increased early (1 and 3 wk), but urinary excretion of isoprostane and H(2)O(2) was only increased after 6 wk of ANG II. An increased in plasma ADMA after 6 wk of ANG II was associated with increased lung protein arginine methyltransferase-1 abundance and decreased renal cortex dimethylarginine dimethylaminohydrolase activity. No changes in renal cortex ADMA were observed. ANG II hypertension in the absence of renal injury is not associated with increased ADMA; however, when the severity and duration of the treatment were increased, plasma ADMA increased. These data suggest that elevated blood pressure alone, for up to 3 wk, in the absence of renal injury does not play an important role in the regulation of ADMA. However, the presence of renal injury and sustained hypertension for 6 wk increases ADMA levels and contributes to nitric oxide deficiency and cardiovascular disease.
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Registered trials
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