ArticleProceedings of the National Academy of Sciences of the United States of America2009
Secretagogin is a Ca2+-binding protein specifying subpopulations of telencephalic neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 66 citations in OpenAlex.
- Neuronal activity modulates the expression of secretagogin, a CaActa physiologica (Oxford, England) · 2025Article
- Secretagogin regulates asynchronous and spontaneous glutamate release in hippocampal neurons through interaction with Doc2α.Life medicine · 2023Article
- Immunohistochemical distribution of secretagogin in the mouse brain.Frontiers in neuroanatomy · 2023Article
- Rabies virus infection is associated with alterations in the expression of parvalbumin and secretagogin in mice brain.Metabolic brain disease · 2021Article
- New Approach for Untangling the Role of Uncommon Calcium-Binding Proteins in the Central Nervous System.Brain sciences · 2021Review
- Secretagogin expression in the mouse olfactory bulb under sensory impairments.Scientific reports · 2020Article
- Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice.The Journal of comparative neurology · 2020Article
- Postnatal Developmental Expression Profile Classifies the Indusium Griseum as a Distinct Subfield of the Hippocampal Formation.Frontiers in cell and developmental biology · 2020Article
- Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams.The Journal of comparative neurology · 2019Article
- Secretagogin expression in the vertebrate brainstem with focus on the noradrenergic system and implications for Alzheimer's disease.Brain structure & function · 2019Article
- GABAergic Medial Septal Neurons with Low-Rhythmic Firing Innervating the Dentate Gyrus and Hippocampal Area CA3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease.International journal of molecular sciences · 2019Review
- 20 Years of Secretagogin: Exocytosis and Beyond.Frontiers in molecular neuroscience · 2019Article
- Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.The EMBO journal · 2018Article
- Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.The Journal of comparative neurology · 2018Article
- Calcium Ion Induced Structural Changes Promote Dimerization of Secretagogin, Which Is Required for Its Insulin Secretory Function.Scientific reports · 2017Article
- Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Developmental and adult characterization of secretagogin expressing amacrine cells in zebrafish retina.PloS one · 2017Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 5 countries.
Funding
Abstract
The Ca(2+)-binding proteins (CBPs) parvalbumin, calbindin, and calretinin are phenotypic markers of terminally differentiated neurons in the adult brain. Although subtle phylogenetic variations in the neuronal distribution of these CBPs may occur, morphologically and functionally diverse subclasses of interneurons harbor these proteins in olfactory and corticolimbic areas. Secretagogin (scgn) is a recently cloned CBP from pancreatic beta and neuroendocrine cells. We hypothesized that scgn is expressed in the mammalian brain. We find that scgn is a marker of neuroblasts commuting in the rostral migratory stream. Terminally differentiated neurons in the olfactory bulb retain scgn expression, with scgn being present in periglomerular cells and granular layer interneurons. In the corticolimbic system, scgn identifies granule cells distributed along the dentate gyrus, indusium griseum, and anterior hippocampal continuation emphasizing the shared developmental origins, and cytoarchitectural and functional similarities of these neurons. We also uncover unexpected phylogenetic differences in scgn expression, since this CBP is restricted to primate cholinergic basal forebrain neurons. Overall, we characterize scgn as a neuron-specific CBP whose distribution identifies neuronal subtypes and hierarchical organizing principles in the mammalian brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.