ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response.Mucosal immunology · 2022Article
- Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa.Mucosal immunology · 2021Article
- Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update.Inflammopharmacology · 2020Review
- Expression Efficiency of MultipleImmunoHorizons · 2020Article
- IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Isolation and functional characterisation of lamina propria leukocytes from helminth-infected, murine small intestine.Journal of immunological methods · 2020Article
- Regulation of T Helper Cell Fate by TCR Signal Strength.Frontiers in immunology · 2020Review
- IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.Scientific reports · 2017Article
- Intestinal helminth infection impacts the systemic distribution and function of the naive lymphocyte pool.Mucosal immunology · 2017Article
- Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths.The Journal of experimental medicine · 2017Article
- IL-4-producing ILC2s are required for the differentiation of TMucosal immunology · 2016Article
- Alternatively Activated Mononuclear Phagocytes from the Skin Site of Infection and the Impact of IL-4Rα Signalling on CD4+T Cell Survival in Draining Lymph Nodes after Repeated Exposure to Schistosoma mansoni Cercariae.PLoS neglected tropical diseases · 2016Article
- TCR Signal Strength Alters T-DC Activation and Interaction Times and Directs the Outcome of Differentiation.Frontiers in immunology · 2016Review
- Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The potential for genetically altered microglia to influence glioma treatment.CNS & neurological disorders drug targets · 2013Review
- NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways.Journal of translational medicine · 2013Article
- Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity.PloS one · 2013Article
- Influence of endogenous opioid systems on T lymphocytes as assessed by the knockout of mu, delta and kappa opioid receptors.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Article
- A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
IL-4 promotes Th2 differentiation and provides immunity to helminth infections but is also associated with allergy and asthma. This suggests that precise adjustment of IL-4 responsiveness is needed to correctly balance immune responses. The IL-4Ralpha chain is an essential component of the IL-4 receptor and signals via STAT6. In this study, we show that infection with a helminth pathogen elicited broad upregulation of IL-4Ralpha on bystander CD4+ T cells in the draining lymph node, while simultaneously resulting in the loss of IL-4Ralpha expression on activated Th2 cells. IL-4Ralpha upregulation was restricted to the reactive lymph node, occurred within 4 d of infection, and was driven by an IL-4- and STAT6-dependent mechanism. Mice heterozygous for Stat6 exhibited reduced IL-4Ralpha upregulation and a correspondingly attenuated Th2 response. Indeed, the enhanced IL-4Ralpha upregulation in BALB/c mice, compared with that in C57BL6 mice, predicted their stronger Th2 response. The selective downregulation of IL-4Ralpha on highly activated Th cells was triggered by antigenic stimulation, was accompanied by loss of IL-7Ralpha, and rendered the cells unresponsive to IL-4. Together these data reveal a tightly controlled program of changing IL-4 responsiveness that characterizes the initiation, amplification, and restriction of a Th2 response in vivo.
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