ReviewJournal of autoimmunity2010
Light, including ultraviolet.
Review in Journal of autoimmunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07600463 (UVC in Prevention of Surgical Wound Infection), which is not on this map. Cited by 95 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
UVC in Prevention of Surgical Wound Infection
Who cites it
95 citing papers in PubMed, 2 syntheses or guidelines pooled it, 243 citations in OpenAlex.
- A review of strategies and their effectiveness in reducing indoor airborne transmission and improving indoor air quality.Environmental research · 2022Pooled it
- Aspirin and nonsteroidal anti-inflammatory drugs can prevent cutaneous squamous cell carcinoma: a systematic review and meta-analysis.The Journal of investigative dermatology · 2015Pooled it
- Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate.JCI insight · 2019Trial
- Pterostilbene and resveratrol: Exploring their protective mechanisms against skin photoaging - A scoping review.Biochemistry and biophysics reports · 2025Review
- Ultraviolet C Decontamination Devices in a Hospital Pharmacy: An Evaluation of Their Contribution.Pharmacy (Basel, Switzerland) · 2025Article
- A Mini-Review of the Potential Health Impacts of Indoor Radiation Exposure in Companion Animals.Environmental health insights · 2025Review
- Sunscreen use associated with elevated prevalence of anti-nuclear antibodies in U.S. adults.Journal of autoimmunity · 2024Article
- Article
- Inhibition of UVB radiation-induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene.Photodermatology, photoimmunology & photomedicine · 2024Article
- Liquiritin Carbomer Gel Cold Paste Promotes Healing of Solar Dermatitis in Mice.International journal of molecular sciences · 2024Article
- Article
- Comparison of the efficacy of physical and chemical strategies for the inactivation of biofilm cells of foodborne pathogens.Food science and biotechnology · 2023Review
- Nonionizing Electromagnetic Irradiations; Biological Interactions, Human Safety.Journal of biomedical physics & engineering · 2023Review
- Phototherapy and DNA Damage: A Systematic Review.The Journal of clinical and aesthetic dermatology · 2023Article
- Phototherapy and risk of developmental delay: the Japan Environment and Children's Study.European journal of pediatrics · 2023Observational
- Exploring the memory: existing activity-dependent tools to tag and manipulate engram cells.Frontiers in cellular neuroscience · 2023Review
- IOC consensus statement on recommendations and regulations for sport events in the heat.British journal of sports medicine · 2023Article
- The role of sirtuins in dermal fibroblast function.Frontiers in medicine · 2023Review
- Combined Toxicological Effects of Di (2-Ethylhexyl) Phthalate and UV-B Irradiation through Endoplasmic Reticulum Stress-Tight Junction Disruption in Human HaCaT Keratinocytes.International journal of molecular sciences · 2022Article
- Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Ultraviolet (UV) light is intricately linked to the functional status of the cutaneous immune system. In susceptible individuals, UV radiation can ignite pathogenic inflammatory pathways leading to allergy or autoimmunity. In others, this same UV radiation can be used as a phototherapy to suppress pathogenic cutaneous immune responses. These vastly different properties are a direct result of UV light's ability to ionize molecules in the skin and thereby chemically alter them. Sometimes these UV-induced chemical reactions are essential, the formation of pre-vitamin D(3) from 7-dehydrocholesterol, for example. In other instances they can be potentially detrimental. UV radiation can ionize a cell's DNA causing adjacent pyrimidine bases to chemically bond to each other. To prevent malignant transformation, a cell may respond to this UV-induced DNA damage by undergoing apoptosis. Although this pathway prevents skin cancer it also has the potential of inducing or exacerbating autoreactive immune responses by exposing the cell's nuclear antigens. Ultraviolet-induced chemical reactions can activate the immune system by a variety of other mechanisms as well. In response to UV irradiation keratinocytes secrete cytokines and chemokines, which activate and recruit leukocytes to the skin. In some individuals UV-induced chemical reactions can synthesize novel antigens resulting in a photoallergy. Alternatively, photosensitizing molecules can damage cells by initiating sunburn-like phototoxic reactions. Herein we review all types of UV-induced skin reactions, especially those involving the immune system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.