ArticleNeurobiology of learning and memory2010
Trace and contextual fear conditioning is enhanced in mice lacking the alpha4 subunit of the GABA(A) receptor.
Article in Neurobiology of learning and memory, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 74 citations in OpenAlex.
- A novel finding on sex-dependent diverse behavioral responses to the anticipation of a threat in a rat model of fear conditioning with the involvement of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex.Learning & behavior · 2026Article
- The role of GABANeuroscience and biobehavioral reviews · 2026Review
- Contextual fear conditioning leads to hypo-innervation of the left ventricular myocardium in female but not male C57BL/6J mice.IBRO neuroscience reports · 2026Article
- Article
- Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility.Molecular brain · 2024Article
- Behavioral outputs and overlapping circuits between conditional fear and active avoidance.Neurobiology of learning and memory · 2024Review
- Knockout of AMPA receptor binding protein Neuron-Specific Gene 2 (NSG2) enhances associative learning and cognitive flexibility.Research square · 2024Article
- Fear-Conditioning to Unpredictable Threats Reveals Sex and Strain Differences in Rat Fear-Potentiated Startle (FPS).Neuroscience · 2023Article
- Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors.Cellular and molecular life sciences : CMLS · 2023Article
- Fear-conditioning to unpredictable threats reveals sex differences in rat fear-potentiated startle (FPS).bioRxiv : the preprint server for biology · 2023Article
- Sex differences in fear responses: Neural circuits.Neuropharmacology · 2023Review
- Abnormal Expression of Synaptic and Extrasynaptic GABAInternational journal of molecular sciences · 2022Article
- Sex differences in contextual fear learning and generalization: a behavioral and computational analysis of hippocampal functioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Assessing the importance of sex in a hippocampus-dependent behavioral test battery in C57BL/6NTac mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Prefrontal GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Pathway-specific GABAergic inhibition contributes to the gain of resilience against anorexia-like behavior of adolescent female mice.Frontiers in behavioral neuroscience · 2022Article
- Neuronal Ensembles Organize Activity to Generate Contextual Memory.Frontiers in behavioral neuroscience · 2022Review
- Review
- Article
- GABAIUPHAR/BPS guide to pharmacology CITE · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The GABA(A)R alpha4 subunit is highly expressed in the dentate gyrus region of the hippocampus at predominantly extra synaptic locations where, along with the GABA(A)R delta subunit, it forms GABA(A) receptors that mediate a tonic inhibitory current. The present study was designed to test hippocampus-dependent and hippocampus-independent learning and memory in GABA(A)R alpha4 subunit-deficient mice using trace and delay fear conditioning, respectively. Mice were of a mixed C57Bl/6J X 129S1/X1 genetic background from alpha4 heterozygous breeding pairs. The alpha4-knockout mice showed enhanced trace and contextual fear conditioning consistent with an enhancement of hippocampus-dependent learning and memory. These enhancements were sex-dependent, similar to previous studies in GABA(A)R delta knockout mice, but differences were present in both males and females. The convergent findings between alpha4 and delta knockout mice suggests that tonic inhibition mediated by alpha4betadelta GABA(A) receptors negatively modulates learning and memory processes and provides further evidence that tonic inhibition makes important functional contributions to learning and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.