Evidence map›Paper›PMID 20018236›Full record

ArticleBrain, behavior, and immunity2010

Dynamics of telomerase activity in response to acute psychological stress.

Elissa S Epel, Jue Lin, Firdaus S Dhabhar, Owen M Wolkowitz, E Puterman, Lori Karan, Elizabeth H Blackburn

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03429309 (The Association Between Telomere Length in Peripheral Blood Leukocyte and Propofol Dose in Anesthesia-induction), which is not on this map. Cited by 106 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03429309 naunknown statusnot on this mapstarted 2017, after this paper: background citation

The Association Between Telomere Length in Peripheral Blood Leukocyte and Propofol Dose in Anesthesia-induction

TypeinterventionalSponsorGuangzhou General Hospital of Guangzhou Military CommandRan2017 to 2018Enrolled100ConditionsGeneral AnesthesiaArmsPropofol
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 1 synthesis or guideline pooled it, 218 citations in OpenAlex.

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  16. The researcher's guide to selecting biomarkers in mental health studies.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Elissa S EpelDepartment of Psychiatry, University of California, San Francisco, 3333 Calif St., Suite 465, San Francisco, CA 94143, USA. eepel@lppi.ucsf.edu
Jue Lin
Firdaus S Dhabhar
Owen M Wolkowitz
E Puterman
Lori Karan
Elizabeth H Blackburn
University of California, San Francisco · USStanford University · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Depression, Stress &Health: Role of Anabolic HormonesK08MH064110 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S. · 2002 to 2006
$807k
Chronic and Acute Psychosocial Stress and Impaired Cell AgingR56AG030424 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S. · 2008 to 2009
$260k
NCRR NIH HHS UL1 RR024131NIA NIH HHS R56 AG030424NIMH NIH HHS K08 MH064110PHS HHS K08PHS HHS R56
6 · The paper itself

Abstract

Telomerase activity plays an essential role in cell survival, by lengthening telomeres and promoting cell growth and longevity. It is now possible to quantify the low levels of telomerase activity in human leukocytes. Low basal telomerase activity has been related to chronic stress in people and to chronic glucocorticoid exposure in vitro. Here we test whether leukocyte telomerase activity changes under acute psychological stress. We exposed 44 elderly women, including 22 high stress dementia caregivers and 22 matched low stress controls, to a brief laboratory psychological stressor, while examining changes in telomerase activity of peripheral blood mononuclear cells (PBMCs). At baseline, caregivers had lower telomerase activity levels than controls, but during stress telomerase activity increased similarly in both groups. Across the entire sample, subsequent telomerase activity increased by 18% one hour after the end of the stressor (p<0.01). The increase in telomerase activity was independent of changes in numbers or percentages of monocytes, lymphocytes, and specific T cell types, although we cannot fully rule out some potential contribution from immune cell redistribution in the change in telomerase activity. Telomerase activity increases were associated with greater cortisol increases in response to the stressor. Lastly, psychological response to the tasks (greater threat perception) was also related to greater telomerase activity increases in controls. These findings uncover novel relationships of dynamic telomerase activity with exposure to an acute stressor, and with two classic aspects of the stress response - perceived psychological stress and neuroendocrine (cortisol) responses to the stressor.

Indexed as

Acute DiseaseAgedAged, 80 and overCaregiversCase-Control StudiesDementiaFemaleFlow CytometryHumansHydrocortisoneLeukocytes, MononuclearLymphocytesMiddle AgedMonocytesNeuropsychological TestsSalivaHydrocortisoneTelomerase

Identifiers

PMID20018236
PMCPMC2856774
OpenAlexW2093473156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.