ReviewNeuropharmacology
From synapse to nucleus: novel targets for treating depression.
Review in Neuropharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- SIRT1 Coordinates Transcriptional Regulation of Neural Activity and Modulates Depression-Like Behaviors in the Nucleus Accumbens.Biological psychiatry · 2024Article
- 5-HTInternational journal of molecular sciences · 2024Article
- Upregulation of brain-derived neurotrophic factor by Shiikuwasha (Citrus depressa Hayata).Journal of pharmaceutical health care and sciences · 2023Article
- Identification of brain areas in mice with peak neural activity across the acute and persistent phases of post-traumatic headache.Cephalalgia : an international journal of headache · 2023Article
- Analysis of Antidepressant-like Effects and Action Mechanisms of GSB-106, a Small Molecule, Affecting the TrkB Signaling.International journal of molecular sciences · 2021Article
- Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments.Current issues in molecular biology · 2021Article
- Review
- Hippocampal mossy cell involvement in behavioral and neurogenic responses to chronic antidepressant treatment.Molecular psychiatry · 2020Article
- Purpurin exerted antidepressant-like effects on behavior and stress axis reactivity: evidence of serotonergic engagement.Psychopharmacology · 2020Article
- Regulation of Circadian Genes by the MAPK Pathway: Implications for Rapid Antidepressant Action.Neuroscience bulletin · 2020Review
- Additive antidepressant-like effects of fasting with β-estradiol in mice.Journal of cellular and molecular medicine · 2019Article
- Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity.Scientific reports · 2019Article
- JNK Regulation of Depression and Anxiety.Brain plasticity (Amsterdam, Netherlands) · 2018Review
- The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor.CNS neuroscience & therapeutics · 2018Article
- Creatine Prevents Corticosterone-Induced Reduction in Hippocampal Proliferation and Differentiation: Possible Implication for Its Antidepressant Effect.Molecular neurobiology · 2017Article
- New targets for rapid antidepressant action.Progress in neurobiology · 2017Review
- Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression.Biological psychiatry · 2017Review
- Antidepressant-Like Effect of Isorhynchophylline in Mice.Neurochemical research · 2017Article
- SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The need for newer compounds to treat depression is an ever-growing concern due to the enormous societal and financial ramifications of this disorder. Here, we review some of the candidate systems that could potentially be involved in depression, or an inherent resistance to depression termed resilience, and the numerous protein targets for these systems. A substantial body of literature provides strong evidence that neurotrophic factors, glutamate receptors, hypothalamic feeding peptides, nuclear hormone receptors, and epigenetic mechanisms, among others, will make for interesting targets when examining depressive behavior or resilience in preclinical models, and eventually clinical trials. Although some of these targets for depression already appear promising, new waves of more selective compounds for any molecular system should promote a better understanding of this complex disease and perhaps improved treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.