ArticleBMC proceedings2009
Genome-wide association studies using single-nucleotide polymorphisms versus haplotypes: an empirical comparison with data from the North American Rheumatoid Arthritis Consortium.
Article in BMC proceedings, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice.Genetics · 2020Article
- A TOMM40/APOE allele encoding APOE-E3 predicts high likelihood of late-onset Alzheimer's disease in autopsy cases.Molecular genetics & genomic medicine · 2020Article
- Genomic Prediction Accuracy of Seven Breeding Selection Traits Improved by QTL Identification in Flax.International journal of molecular sciences · 2020Article
- Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset.Journal of advanced research · 2019Article
- Article
- Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer.Cancer discovery · 2017Article
- Genetic Biomarkers to Identify the Risk of Osteonecrosis in Children with Acute Lymphoblastic Leukemia.Molecular diagnosis & therapy · 2016Article
- Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis.Journal of advanced research · 2016Review
- Single nucleotide polymorphism and haplotype effects associated with somatic cell score in German Holstein cattle.Genetics, selection, evolution : GSE · 2014Article
- Efficient haplotype block recognition of very long and dense genetic sequences.BMC bioinformatics · 2014Article
- Genome-wide association studies using haplotypes and individual SNPs in Simmental cattle.PloS one · 2014Article
- Article
- A two-marker haplotype in the IRF5 gene is associated with inflammatory bowel disease in a North American cohort.Genes and immunity · 2012Article
- Rule-based induction method for haplotype comparison and identification of candidate disease loci.Genome medicine · 2012Article
- Improved risk prediction for Crohn's disease with a multi-locus approach.Human molecular genetics · 2011Article
- Performance of single nucleotide polymorphisms versus haplotypes for genome-wide association analysis in barley.PloS one · 2010Article
- Haplotype-based analysis: a summary of GAW16 Group 4 analysis.Genetic epidemiology · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The high genomic density of the single-nucleotide polymorphism (SNP) sets that are typically surveyed in genome-wide association studies (GWAS) now allows the application of haplotype-based methods. Although the choice of haplotype-based vs. individual-SNP approaches is expected to affect the results of association studies, few empirical comparisons of method performance have been reported on the genome-wide scale in the same set of individuals. To measure the relative ability of the two strategies to detect associations, we used a large dataset from the North American Rheumatoid Arthritis Consortium to: 1) partition the genome into haplotype blocks, 2) associate haplotypes with disease, and 3) compare the results with individual-SNP association mapping. Although some associations were shared across methods, each approach uniquely identified several strong candidate regions. Our results suggest that the application of both haplotype-based and individual-SNP testing to GWAS should be adopted as a routine procedure.
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