ReviewCritical care (London, England)2009
Clinical review: post-extubation laryngeal edema and extubation failure in critically ill adult patients.
Review in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01857674 (Evaluation of Laryngeal Ultrasonography Performance in Predicting Major Post Extubation Laryngeal Edema in Intensive Care Patients), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Laryngeal Ultrasonography Performance in Predicting Major Post Extubation Laryngeal Edema in Intensive Care Patients
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 163 citations in OpenAlex.
- Comparative efficacies of various corticosteroids for preventing postextubation stridor and reintubation: a systematic review and network meta-analysis.Frontiers in medicine · 2023Pooled it
- Dexamethasone pretreatment for 24 h versus 6 h for prevention of postextubation airway obstruction in children: a randomized double-blind trial.Intensive care medicine · 2014Trial
- Nebulized 0.5, 2.5 and 5 ml L-epinephrine for post-extubation stridor in children: a prospective, randomized, double-blind clinical trial.Intensive care medicine · 2012Trial
- Reintubation in the ICU: A Prospective Observational Study of Its Impact on Recovery Outcomes and Mortality.Cureus · 2026Article
- Article
- Identifying the association between post-extubation laryngeal edema and aspiration in acute respiratory failure patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Observational
- A pragmatic approach to identifying postextubation dysphagia in critically ill surgical patients using the water swallow test.Scientific reports · 2026Article
- Risk factors analysis for extubation failure following mandibular distraction osteogenesis in infants with Pierre Robin sequence: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- All India Difficult Airway Association 2025 guidelines for extubation of the "at-risk" airway.Indian journal of anaesthesia · 2025Article
- Bridging the Gap: The Role of Non-Invasive Respiratory Supports in Weaning from Invasive Mechanical Ventilation.Journal of clinical medicine · 2025Review
- Oropharyngeal ultrafast ultrasound measurements in mechanically ventilated critically ill patients do not identify post-extubation stridor.Critical care (London, England) · 2025Observational
- Liberation from invasive mechanical ventilation: a nationwide survey among intensive care units in the Netherlands.BMJ open respiratory research · 2025Article
- Delayed Onset of Post-Intubation Laryngeal Oedema: Navigating Patient Autonomy and Successful Medical Management.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Article
- Prevalence and risk factors of postoperative laryngeal edema in patients undergoing neck dissection.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- New Insight into Laryngo-Tracheal Surgery: High-Flow Oxygen Therapy to Prevent Early Complications after Surgery.Journal of personalized medicine · 2024Article
- Extubation After Acute Brain Injury: An Unsolved Dilemma!!Neurocritical care · 2024Article
- Research progress on high-concentration oxygen therapy after cerebral hemorrhage.Frontiers in neurology · 2024Review
- Time definition of reintubation most relevant to patient outcomes in critically ill patients: a multicenter cohort study.Critical care (London, England) · 2023Article
- Point-of-Care Ultrasound in Airway Evaluation and Management: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laryngeal edema is a frequent complication of intubation. It often presents shortly after extubation as post-extubation stridor and results from damage to the mucosa of the larynx. Mucosal damage is caused by pressure and ischemia resulting in an inflammatory response. Laryngeal edema may compromise the airway necessitating reintubation. Several studies show that a positive cuff leak test combined with the presence of risk factors can identify patients with increased risk for laryngeal edema. Meta-analyses show that pre-emptive administration of a multiple-dose regimen of glucocorticosteroids can reduce the incidence of laryngeal edema and subsequent reintubation. If post-extubation edema occurs this may necessitate medical intervention. Parenteral administration of corticosteroids, epinephrine nebulization and inhalation of a helium/oxygen mixture are potentially effective, although this has not been confirmed by randomized controlled trials. The use of non-invasive positive pressure ventilation is not indicated since this will delay reintubation. Reintubation should be considered early after onset of laryngeal edema to adequately secure an airway. Reintubation leads to increased cost, morbidity and mortality.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.