ArticleInsect molecular biology2010
Analysis of Rickettsia typhi-infected and uninfected cat flea (Ctenocephalides felis) midgut cDNA libraries: deciphering molecular pathways involved in host response to R. typhi infection.
Article in Insect molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Male and Female Cat Fleas (Insects · 2026Article
- Environmental and Host Blood Interactions ShapePathogens (Basel, Switzerland) · 2026Article
- Physiology of the cat flea (Ctenocephalides felis) gut: serine protease activity, midgut pH, and intestinal barrier integrity.Journal of medical entomology · 2026Article
- Chemical modulation of IMD signaling in the cat flea (Current research in insect science · 2026Article
- Interaction of Bacteria and Fleas, Focusing on the Plague Bacterium-A Review.Microorganisms · 2025Review
- Transcriptional induction of the IMD signaling pathway and associated antibacterial activity in the digestive tract of cat fleas (Ctenocephalides felis).Parasites & vectors · 2024Article
- Vector biology of the cat flea Ctenocephalides felis.Trends in parasitology · 2024Review
- Immune Reactions of Vector Insects to Parasites and Pathogens.Microorganisms · 2024Review
- Salivary glands of the cat flea,Current research in insect science · 2024Review
- Feeding on aPathogens (Basel, Switzerland) · 2023Article
- Transposon mutagenesis of Rickettsia felis sca1 confers a distinct phenotype during flea infection.PLoS pathogens · 2022Article
- Using Proteomic Approaches to Unravel the Response ofFrontiers in cellular and infection microbiology · 2022Article
- Unpacking the intricacies of Rickettsia-vector interactions.Trends in parasitology · 2021Review
- Dynamic gene expression in salivary glands of the cat flea during Rickettsia felis infection.Pathogens and disease · 2021Article
- Transcriptomic profiling of the digestive tract of the rat flea, Xenopsylla cheopis, following blood feeding and infection with Yersinia pestis.PLoS neglected tropical diseases · 2020Article
- A reverse vaccinology approach to the identification and characterization of Ctenocephalides felis candidate protective antigens for the control of cat flea infestations.Parasites & vectors · 2018Article
- The Cat Flea (Ctenocephalides felis) Immune Deficiency Signaling Pathway Regulates Rickettsia typhi Infection.Infection and immunity · 2018Article
- Identification of genes associated with blood feeding in the cat flea, Ctenocephalides felis.Parasites & vectors · 2015Article
- The 'ubiquitous' reality of vector immunology.Cellular microbiology · 2013Review
- PATRIC: the comprehensive bacterial bioinformatics resource with a focus on human pathogenic species.Infection and immunity · 2011Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Murine typhus is a flea-borne febrile illness that is caused by the obligate intracellular bacterium, Rickettsia typhi. The cat flea, Ctenocephalides felis, acquires R. typhi by imbibing a bloodmeal from a rickettsemic vertebrate host. To explore which transcripts are expressed in the midgut in response to challenge with R. typhi, cDNA libraries of R. typhi-infected and uninfected midguts of C. felis were constructed. In this study, we examined midgut transcript levels for select C. felis serine proteases, GTPases and defence response genes, all thought to be involved in the fleas response to feeding or infection. An increase in gene expression was observed for the serine protease inhibitors and vesicular trafficking proteins in response to feeding. In addition, R. typhi infection resulted in an increase in gene expression for the chymotrypsin and rab5 that we studied. Interestingly, R. typhi infection had little effect on expression of any of the defence response genes that we studied. We are unsure as to the physiological significance of these gene expression profiles and are currently investigating their potential roles as it pertains to R. typhi infection. To our knowledge, this is the first report of differential expression of flea transcripts in response to infection with R. typhi.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.