Evidence map›Paper›PMID 20017521›Full record

ArticleOrganic letters2010

Regioselective intramolecular dipolar cycloaddition of azides and unsymmetrical alkynes.

Ryan A Brawn, Morgan Welzel, Jason T Lowe, James S Panek

Abstract read
In one paragraph

Article in Organic letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryan A BrawnDepartment of Chemistry and Center for Chemical Methodology and Library Development, Metcalf Center for Science and Engineering, 590 Commonwealth Avenue, Boston University, Boston, Massachusetts 02215, USA.
Morgan Welzel
Jason T Lowe
James S Panek

Funding

ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTSR01CA056304 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI PANEK, JAMES S. · 1994 to 2006
$2.2M
NCI NIH HHS CA 53604NCI NIH HHS R01 CA056304
6 · The paper itself

Abstract

Enantioenriched allenylsilanes are used in three-component propargylation reactions with aldehydes and silyl ethers to form syn-homopropargylic ethers that contain an imbedded azide. These materials then undergo thermally induced intramolecular 1,3-dipolar cycloaddition reactions, resulting in unique fused ring systems containing 1,2,3-triazoles. The ability to modify all three components of the reaction allows for expedient access to compounds containing significant structural and stereochemical variation.

Indexed as

AldehydesAlkynesAzidesCyclizationEthersMolecular ConformationStereoisomerismAldehydesAlkynesAzidesEthers

Identifiers

PMID20017521
PMCPMC3164318

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.