Evidence map›Paper›PMID 20017502›Full record

ArticleNano letters2010

Insights from a nanoparticle minuet: two-dimensional membrane profiling through silver plasmon ruler tracking.

Guoxin Rong, Hongyun Wang, Björn M Reinhard

Open access · greenAbstract read
In one paragraph

Article in Nano letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 45 citations in OpenAlex.

  1. Plasmonic Nanostructure Biosensors: A Review.Sensors (Basel, Switzerland) · 2023
    Review
  2. Review
  3. Recent Developments in Nanosensors for Imaging Applications in Biological Systems.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019
    Review
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  11. Review
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  15. Design and Implementation of Noble Metal Nanoparticle Cluster Arrays for Plasmon Enhanced Biosensing.The journal of physical chemistry. C, Nanomaterials and interfaces · 2011
    Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Guoxin RongDepartment of Chemistry and The Photonics Center, Boston University, Boston, Massachusetts 02215, USA.
Hongyun Wang
Björn M Reinhard
Boston University · US

Funding

Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor Signal Transduction Pathway Using Plasmon CouplingR01CA138509 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Bjoern Markus Reinhard · 2009 to 2026
$5.9M
Plasmon Coupling Microscopy for the in vivo Detection and Tracking of CytoplasmicR21EB008822 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI REINHARD, BJOERN MARKUS · 2008 to 2009
$431k
NCI NIH HHS 1 R01 CA138509-01NCI NIH HHS R01 CA138509NIBIB NIH HHS 5 R21 EB008822-02NIBIB NIH HHS R21 EB008822
6 · The paper itself

Abstract

Individual pairs of polymer-tethered silver nanoparticles, so-called silver plasmon rulers, enable distance and orientation measurements on the nanoscale. The reduced linear dichroism and the spectrum of the light scattered from individual plasmon rulers encode information about their orientation and average interparticle separation, respectively. We took advantage of the gain in information silver plasmon rulers offer as probes in optical tracking and analyzed the translational and rotational motions as well as the extension of individual silver plasmon rulers diffusing on the plasma membrane of lysed HeLa cells. Consistent with a compartmentalization of the cell surface on the length scales of the plasmon rulers, most rulers were either immobilized or performed a confined lateral diffusion. Structural details of a plasmon ruler's confinement region became accessible utilizing the orientation and interparticle separation dependent optical response of the plasmon rulers. This approach, which we refer to as polarization-resolved plasmon coupling microscopy, enabled a detailed structural characterization of individual membrane compartments and provided a quantitative metrics to characterize the structural lateral heterogeneity of cell membranes on submicrometer length scales. In combination with adequate tracking methods, the "dance" performed by membrane confined dimers of flexibly linked noble metal nanoparticles revealed deep insight into the underlying membrane morphology.

Indexed as

Cell MembraneDiffusionEquipment DesignHeLa CellsHumansLightMetal NanoparticlesModels, StatisticalNanostructuresNanotechnologyPolymersScattering, RadiationSilverPolymersSilver

Identifiers

PMID20017502
PMCPMC2865136
OpenAlexW2121276849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.