ArticleJournal of the American Chemical Society2010
The role of the substrate lipid in processive glycan polymerization by the peptidoglycan glycosyltransferases.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Peptidoglycan polymerase function and regulation.Microbiology and molecular biology reviews : MMBR · 2025Review
- Chemoenzymatic Preparation of aACS omega · 2023Article
- Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases.Journal of the American Chemical Society · 2019Article
- Insight into Elongation Stages of Peptidoglycan Processing in Bacterial Cytoplasmic Membranes.Scientific reports · 2018Article
- Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor.Bioorganic & medicinal chemistry letters · 2018Article
- In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins.Nature chemical biology · 2017Article
- Structural Insights into Inhibition of Escherichia coli Penicillin-binding Protein 1B.The Journal of biological chemistry · 2017Article
- Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials.Antibiotics (Basel, Switzerland) · 2016Review
- Activities and regulation of peptidoglycan synthases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Tuning the production of variable length, fluorescent polyisoprenoids using surfactant-controlled enzymatic synthesis.Biochemistry · 2015Article
- Iminosugar C-glycoside analogues of α-D-GlcNAc-1-phosphate: synthesis and bacterial transglycosylase inhibition.The Journal of organic chemistry · 2014Article
- Prospects for novel inhibitors of peptidoglycan transglycosylases.Bioorganic chemistry · 2014Review
- Lipoprotein activators stimulate Escherichia coli penicillin-binding proteins by different mechanisms.Journal of the American Chemical Society · 2014Article
- Fluorescent probes for investigation of isoprenoid configuration and size discrimination by bactoprenol-utilizing enzymes.Bioorganic & medicinal chemistry · 2013Article
- Forming cross-linked peptidoglycan from synthetic gram-negative Lipid II.Journal of the American Chemical Society · 2013Article
- Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors.Journal of the American Chemical Society · 2013Article
- The molecular origins of chiral growth in walled cells.Current opinion in microbiology · 2012Review
- The wciN gene encodes an α-1,3-galactosyltransferase involved in the biosynthesis of the capsule repeating unit of Streptococcus pneumoniae serotype 6B.Biochemistry · 2012Article
- Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics.Tetrahedron · 2011Article
- N-methylimidazolium chloride-catalyzed pyrophosphate formation: application to the synthesis of Lipid I and NDP-sugar donors.Bioorganic & medicinal chemistry letters · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The peptidoglycan glycosyltransferases (PGTs) catalyze the processive polymerization of a C55 lipid-linked disaccharide (Lipid II) to form peptidoglycan, the main component of the bacterial cell wall. Our ability to understand this reaction has been limited due to challenges identifying the appropriate substrate analogues to selectively interrogate the donor (the elongating strand) and acceptor (Lipid II) sites. To address this problem, we have developed an assay using synthetic substrates that can discriminate between the donor and acceptor sites of the PGTs. We have shown that each site has a distinct lipid length preference. We have also established that processive polymerization depends on the length of the lipid attached to the donor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.