ReviewBiomedical chromatography : BMC2010
Analysis of endogenous glutathione-adducts and their metabolites.
Review in Biomedical chromatography : BMC, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Peripheral S-(PGJBMC psychiatry · 2026Article
- Identification and Quantitation ofMethods and protocols · 2025Article
- Screening and identification of reactive metabolic compounds of Cortex Periplocae based on glutathione capture-mass spectrometry.Journal of natural medicines · 2024Article
- The thioesterase APT1 is a bidirectional-adjustment redox sensor.Nature communications · 2023Article
- Reconsidering the Chemical Nature of Strand Breaks Derived from Abasic Sites in Cellular DNA: Evidence for 3'-Glutathionylation.Journal of the American Chemical Society · 2022Article
- Article
- Discovery of New Chemical Tools againstPharmaceuticals (Basel, Switzerland) · 2021Article
- Glutathione conjugates of the mercapturic acid pathway and guanine adduct as biomarkers of exposure to CEES, a sulfur mustard analog.Analytical and bioanalytical chemistry · 2021Article
- The phyto-impact of fluazinam fungicide on cellular structure, agro-physiological, and yield traits of pepper and eggplant crops.Environmental science and pollution research international · 2020Article
- Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.Nature communications · 2019Article
- Temporal dynamic responses of roots in contrasting tomato genotypes to cadmium tolerance.Ecotoxicology (London, England) · 2018Article
- Potential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon 6-Ethylchrysene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells.Chemical research in toxicology · 2016Article
- In vitro Effects of Four Native Brazilian Medicinal Plants in CYP3A4 mRNA Gene Expression, Glutathione Levels, and P-Glycoprotein Activity.Frontiers in pharmacology · 2016Article
- Glutathione efflux and cell death.Antioxidants & redox signaling · 2012Review
- Ultrasensitive sample quantitation via selected reaction monitoring using CITP/CZE-ESI-triple quadrupole MS.Analytical chemistry · 2012Article
- Adductomics: characterizing exposures to reactive electrophiles.Toxicology letters · 2012Article
- Metabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: detection of an adenine B[a]P-7,8-dione adduct.Chemical research in toxicology · 2012Article
- Targeted chiral analysis of bioactive arachidonic Acid metabolites using liquid-chromatography-mass spectrometry.Metabolites · 2012Article
- The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones.Frontiers in pharmacology · 2012Article
- Synthesis of deuterium-labeled analogs of the lipid hydroperoxide-derived bifunctional electrophile 4-oxo-2(Journal of labelled compounds & radiopharmaceuticals · 2011Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The ability to conduct validated analyses of glutathione (GSH)-adducts and their metabolites is critically important in order to establish whether they play a role in cellular biochemical or pathophysiological processes. The use of stable isotope dilution (SID) methodology in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides the highest bioanalytical specificity possible for such analyses. Quantitative studies normally require the high sensitivity that can be obtained by the use of multiple reaction monitoring (MRM)/MS rather than the much less sensitive but more specific full scanning methodology. The method employs a parent ion corresponding to the intact molecule together with a prominent product ion that obtained by collision induced dissociation. Using SID LC-MRM/MS, analytes must have the same relative LC retention time to the heavy isotope internal standard established during the validation procedure, the correct parent ion and the correct product ion. This level of specificity cannot be attained with any other bioanalytical technique employed for biomarker analysis. This review will describe the application of SID LC-MR/MS methodology for the analysis of GSH-adducts and their metabolites. It will also discuss potential future directions for the use of this methodology for rigorous determination of their utility as disease and exposure biomarkers.
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Registered trials
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