ArticleDevelopmental neurobiology2010
Late-postnatal cannabinoid exposure persistently increases FoxP2 expression within zebra finch striatum.
Article in Developmental neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Endocannabinoid signaling in social functioning: an RDoC perspective.Translational psychiatry · 2016Review
- Differential FoxP2 and FoxP1 expression in a vocal learning nucleus of the developing budgerigar.Developmental neurobiology · 2015Article
- Neural FoxP2 and FoxP1 expression in the budgerigar, an avian species with adult vocal learning.Behavioural brain research · 2015Article
- The evolution and comparative neurobiology of endocannabinoid signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learning.Neuron · 2012Article
- Singing under the influence: examining the effects of nutrition and addiction on a learned vocal behavior.Molecular neurobiology · 2011Review
- Late-postnatal cannabinoid exposure persistently elevates dendritic spine densities in area X and HVC song regions of zebra finch telencephalon.Brain research · 2011Article
- Evo-devo, deep homology and FoxP2: implications for the evolution of speech and language.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness.BMC neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Prior work has shown that cannabinoid exposure of zebra finches during sensorimotor stages of vocal development alters song patterns produced in adulthood. We are currently working to identify physiological substrates for this altered song learning. FoxP2 is a transcription factor associated with altered vocal development in both zebra finches and humans. This protein shows a distinct pattern of expression within Area X of striatum that coincides with peak expression of CB(1) cannabinoid receptors during sensorimotor learning. Coincident expression in a brain region essential for song learning led us to test for a potential signaling interaction. We have found that cannabinoid agonists acutely increase expression of FoxP2 throughout striatum. When administered during sensorimotor song learning, cannabinoids increase basal levels of striatal FoxP2 expression in adulthood. Thus, song-altering cannabinoid treatments are associated with persistent increases in basal expression of FoxP2 in zebra finch striatum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.