ReviewPflugers Archiv : European journal of physiology2010
Nicotinic receptor channelopathies and epilepsy.
Review in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Review
- Nicotinic Receptors in Sleep-Related Hypermotor Epilepsy: Pathophysiology and Pharmacology.Brain sciences · 2020Review
- L-3,3',5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors.PloS one · 2019Article
- Synthesis, Structure and Biological Activity of CIA and CIB, Two α-Conotoxins from the Predation-Evoked Venom ofToxins · 2018Article
- Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.Molecular pharmacology · 2015Review
- Conotoxins targeting nicotinic acetylcholine receptors: an overview.Marine drugs · 2014Review
- Structure-function elucidation of a new α-conotoxin, Lo1a, from Conus longurionis.The Journal of biological chemistry · 2014Article
- Genetic matters: thirty years of progress using mouse models in nicotinic research.Biochemical pharmacology · 2013Review
- The role of dopamine signaling in epileptogenesis.Frontiers in cellular neuroscience · 2013Article
- Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?Frontiers in cellular neuroscience · 2013Review
- A common susceptibility factor of both autism and epilepsy: functional deficiency of GABA A receptors.Journal of autism and developmental disorders · 2013Review
- Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors.Biological psychiatry · 2012Article
- Vulnerability to paroxysmal oscillations in delayed neural networks: a basis for nocturnal frontal lobe epilepsy?Chaos (Woodbury, N.Y.) · 2011Article
- Naturally-expressed nicotinic acetylcholine receptor subtypes.Biochemical pharmacology · 2011Review
- Pharmacogenetics of new analgesics.British journal of pharmacology · 2011Review
- Altered intrinsic properties of neuronal subtypes in malformed epileptogenic cortex.Brain research · 2011Article
- Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors.PloS one · 2011Article
- Neurocircuitry of the nicotinic cholinergic system.Dialogues in clinical neuroscience · 2010Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characterized by sudden episodes called seizures, epilepsy was recognized long ago as a neurological disorder that can have multiple forms ranging from benign to life threatening depending upon its severity. Although several evidences indicated that genes play an important role in at least half of the patients, it is only with the advances in molecular biology and genetics that the puzzle about oligogenic and monogenic epilepsies slowly starts to unfold. The finding of an association between a monogenic form of epilepsy and a mutation in the gene encoding the neuronal nicotinic acetylcholine receptor subunit CHRNA4 marked, in 1995, a turning point in our understanding of epilepsy. It also marked the first step towards the today widely acknowledged concept of epilepsies as channelopathies. Several mutations in nicotinic acetylcholine receptor genes have, since then, been identified, and the functional properties of these mutated receptors were characterized. In this work, we review, in the light of the latest discoveries, the effects caused by the mutations on the physiological properties of the receptors and the impact of such mutations on neuronal network functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.