ArticleCytotechnology2009
Establishment and characterization of human osteosarcoma cell lines with different pulmonary metastatic potentials.
Article in Cytotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Feasibility and barriers to rapid establishment of patient-derived primary osteosarcoma cell lines in clinical management.iScience · 2024Review
- Article
- The role of Notch ligand Jagged1 in osteosarcoma proliferation, metastasis, and recurrence.Journal of orthopaedic surgery and research · 2021Article
- Circ_0105346 Knockdown Inhibits Osteosarcoma Development via Regulating miR-1182/WNT7B Axis.Cancer management and research · 2021Article
- Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma.Theranostics · 2020Article
- Self-seeding circulating tumor cells promote the proliferation and metastasis of human osteosarcoma by upregulating interleukin-8.Cell death & disease · 2019Article
- Downregulation of the long non‑coding RNA FOXD2‑AS1 inhibits cell proliferation, migration and invasion in osteosarcoma.Molecular medicine reports · 2019Article
- Overexpression of p62 is associated with poor prognosis and aggressive phenotypes in osteosarcoma.Oncology letters · 2018Article
- Hypoxia promotes chemotherapy resistance by down-regulating SKA1 gene expression in human osteosarcoma.Cancer biology & therapy · 2017Article
- Interleukin-6 suppression reduces tumour self-seeding by circulating tumour cells in a human osteosarcoma nude mouse model.Oncotarget · 2016Article
- CXCR4-targeted near-infrared imaging allows detection of orthotopic and metastatic human osteosarcoma in a mouse model.Scientific reports · 2015Article
- SDF-1/CXCR4 promotes F5M2 osteosarcoma cell migration by activating the Wnt/β-catenin signaling pathway.Medical oncology (Northwood, London, England) · 2015Article
- MicroRNA profiling identifies MiR-195 suppresses osteosarcoma cell metastasis by targeting CCND1.Oncotarget · 2015Article
- Interleukin-11 receptor α is overexpressed in human osteosarcoma, and near-infrared-labeled IL-11Rα imaging agent could detect osteosarcoma in mouse tumor xenografts.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Genomic instability of osteosarcoma cell lines in culture: impact on the prediction of metastasis relevant genes.PloS one · 2015Article
- microRNA-194 suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targeting CDH2 and IGF1R.International journal of oncology · 2014Article
- Homologous mesenchymal stem cells promote the emergence and growth of pulmonary metastases of the rat osteosarcoma cell line UMR-106.Oncology letters · 2014Article
- Tumor self-seeding by circulating tumor cells in nude mouse models of human osteosarcoma and a preliminary study of its mechanisms.Journal of cancer research and clinical oncology · 2014Article
- Hypoxia promotes migration and induces CXCR4 expression via HIF-1α activation in human osteosarcoma.PloS one · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To develop an investigative tool for the study of human osteosarcoma (OSA), we established a human OSA cell line, namely, SOSP-9607, which exhibits a potential for spontaneous pulmonary metastasis. Subsequently, we screened two related sublines (F5M2 and F4) that have different pulmonary metastatic potentials. An in vivo orthotopic transplantation assay confirmed spontaneous pulmonary metastasis in all mice (100%) transplanted with the more aggressive OSA cells (F5M2) and a lesser degree of metastases with smaller nodules in 33.3% mice transplanted with the less aggressive OSA cell subline (F4). In mice transplanted with F5M2 cells, death from metastasis occurred at a median of 71 days; however, in mice transplanted with F4, no death occurred even after 120 days. Therefore, the F5M2 and F4 sublines, which originated from the same parent cell line, differed with respect to metastasis-related properties such as proliferating ability and invasiveness. Hence, these well-characterized human OSA sublines can be used as valuable models for comparative studies of genetic determinants of OSA in the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.