ArticlePloS one2009
Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- 14-weeks combined exercise epigenetically modulated 118 genes of menopausal women with prediabetes.Frontiers in endocrinology · 2022Article
- Quantity, Quality, and Timing of Carbohydrate Intake and Blood Pressure.Current nutrition reports · 2019Review
- Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations.Journal of personalized medicine · 2018Article
- Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease.The American journal of pathology · 2017Article
- Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.The Journal of clinical investigation · 2017Article
- Outcome Disparities in African American Compared with European American Women with ER+HER2- Tumors Treated within an Equal-Access Health Care System.Ethnicity & disease · 2016Article
- Article
- Gene expression variation between African Americans and whites is associated with coronary artery calcification: the multiethnic study of atherosclerosis.Physiological genomics · 2011Article
- Are the 2005 Dietary Guidelines for Americans Associated With reduced risk of type 2 diabetes and cardiometabolic risk factors? Twenty-year findings from the CARDIA study.Diabetes care · 2011Article
- Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIndividuals of African descent in the United States suffer disproportionately from diseases with a metabolic etiology (obesity, metabolic syndrome, and diabetes), and from the pathological consequences of these disorders (hypertension and cardiovascular disease). METHODOLOGY/PRINCIPAL
findingsUsing a combination of genetic/genomic and bioinformatics approaches, we identified a large number of genes that were both differentially expressed between American subjects self-identified to be of either African or European ancestry and that also contained single nucleotide polymorphisms that distinguish distantly related ancestral populations. Several of these genes control the metabolism of simple carbohydrates and are direct targets for the SREBP1, a metabolic transcription factor also differentially expressed between our study populations. CONCLUSIONS/SIGNIFICANCE: These data support the concept of stable patterns of gene transcription unique to a geographic ancestral lineage. Differences in expression of several carbohydrate metabolism genes suggest both genetic and transcriptional mechanisms contribute to these patterns and may play a role in exacerbating the disproportionate levels of obesity, diabetes, and cardiovascular disease observed in Americans with African ancestry.
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Registered trials
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