ArticleHelvetica chimica acta1999
Novel Nucleoside Analogues with Fluorophores Replacing the DNA Base.
Article in Helvetica chimica acta, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 80 citations in OpenAlex.
- Pattern-based detection of toxic metals in surface water with DNA polyfluorophores.Angewandte Chemie (International ed. in English) · 2014Article
- Genetically encoded multispectral labeling of proteins with polyfluorophores on a DNA backbone.Journal of the American Chemical Society · 2013Article
- Differentiating between fluorescence-quenching metal ions with polyfluorophore sensors built on a DNA backbone.Journal of the American Chemical Society · 2011Article
- Selective sensor for silver ions built from polyfluorophores on a DNA backbone.Organic letters · 2010Article
- Fluorescent analogs of biomolecular building blocks: design, properties, and applications.Chemical reviews · 2010Review
- Polyfluorophores on a DNA backbone: a multicolor set of labels excited at one wavelength.Journal of the American Chemical Society · 2009Article
- Enzymatic incorporation of emissive pyrimidine ribonucleotides.Chemistry, an Asian journal · 2009Article
- Furan Decorated Nucleoside Analogues as Fluorescent Probes: synthesis, photophysical evaluation and site-specific incorporation.Tetrahedron · 2007Article
- Fluorescent pyrimidine ribonucleotide: synthesis, enzymatic incorporation, and utilization.Journal of the American Chemical Society · 2007Article
- Exploring the limits of DNA size: naphtho-homologated DNA bases and pairs.Journal of the American Chemical Society · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We describe the preparation and fluorescence properties of a set of new nucleosides in which a known hydrocarbon or oligothiophene fluorophore replaces the DNA base at C(1) of the deoxyribose moiety (see 3a - f). These compounds are potentially useful as probes in the study of the structure and dynamics of nucleic acids and their complexes with proteins. In addition, they may find use as fluorescent labels for nucleic-acid-based biomedical diagnostics methods. The fluorophores conjugated to deoxyribose at C(1) in the α-d-form include terphenyl, stilbene, terthiophene, benzoterthiophene, and pyrene. Also included is a non-fluorescent spacer in which cyclohexene replaces the DNA base. The nucleosides are derived from brominated fluorophore precursors and Hoffer's 2-deoxy-3,5-di-O-(p-toluoyl)-d-ribofuranosyl chloride. The emission maxima of the free nucleosides range from 345 to 536 nm. Also described are the 5'-(dimethoxytrityl) 3'-O-phosphoramidite derivatives 5a - f, suitable for incorporation into oligonucleotides by automated synthesizers.
Identifiers
20016809PMC2788824W2064008357What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.