ArticleNature2009
Growth landscape formed by perception and import of glucose in yeast.
Article in Nature, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Analysing and meta-analysing time-series data of microbial growth and gene expression from plate readers.PLoS computational biology · 2022Pooled it
- Glucose repression ofbioRxiv : the preprint server for biology · 2026Article
- Dynamic patterns of gene expression match extracellular signals through push-pull regulation.PLoS genetics · 2025Article
- A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations.PLoS computational biology · 2025Article
- Robustness of mitochondrial biogenesis and respiration explain aerobic glycolysis.bioRxiv : the preprint server for biology · 2024Article
- Vertical growth dynamics of biofilms.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The regulatory mechanism of the yeast osmoresponse under different glucose concentrations.iScience · 2023Article
- Using Kinetic Modelling to Infer Adaptations inMetabolites · 2023Article
- Quiescence inAnnual review of genetics · 2022Review
- Predicting the re-distribution of antibiotic molecules caused by inter-species interactions in microbial communities.ISME communications · 2022Article
- Multiple nutrient transporters enable cells to mitigate a rate-affinity tradeoff.PLoS computational biology · 2022Article
- Monitoring Intracellular Metabolite Dynamics inMetabolites · 2022Article
- A yeast FRET biosensor enlightens cAMP signaling.Molecular biology of the cell · 2021Article
- Differential scaling between G1 protein production and cell size dynamics promotes commitment to the cell division cycle in budding yeast.Nature cell biology · 2019Article
- Article
- Asymmetric distribution of glucose transporter mRNA provides a growth advantage in yeast.The EMBO journal · 2019Article
- Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux.Scientific reports · 2018Article
- Glucose repression can be alleviated by reducing glucose phosphorylation rate in Saccharomyces cerevisiae.Scientific reports · 2018Article
- Late-Arriving Signals Contribute Less to Cell-Fate Decisions.Biophysical journal · 2017Article
- Metabolic adjustment upon repetitive substrate perturbations using dynamicMicrobial cell factories · 2017Article
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Authors and funding
2 authors.
Funding
Abstract
An important challenge in systems biology is to quantitatively describe microbial growth using a few measurable parameters that capture the essence of this complex phenomenon. Two key events at the cell membrane-extracellular glucose sensing and uptake-initiate the budding yeast's growth on glucose. However, conventional growth models focus almost exclusively on glucose uptake. Here we present results from growth-rate experiments that cannot be explained by focusing on glucose uptake alone. By imposing a glucose uptake rate independent of the sensed extracellular glucose level, we show that despite increasing both the sensed glucose concentration and uptake rate, the cell's growth rate can decrease or even approach zero. We resolve this puzzle by showing that the interaction between glucose perception and import, not their individual actions, determines the central features of growth, and characterize this interaction using a quantitative model. Disrupting this interaction by knocking out two key glucose sensors significantly changes the cell's growth rate, yet uptake rates are unchanged. This is due to a decrease in burden that glucose perception places on the cells. Our work shows that glucose perception and import are separate and pivotal modules of yeast growth, the interaction of which can be precisely tuned and measured.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.