Evidence map›Paper›PMID 20016538›Full record

Trial reportLeukemia2010

Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia.

D-C Liang, C-P Yang, D-T Lin, I-J Hung, K-H Lin, J-S Chen, C-C Hsiao, T-T Chang, C-T Peng, M-T Lin and 28 more

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Leukemia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
  4. Improved prognosis for older adolescents with acute lymphoblastic leukemia.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2011
    Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Antibacterial prophylaxis in pediatric patients with leukemia.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Review
  19. Novel variants inBlood · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 17 institutions in 1 country.

D-C LiangDepartment of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan, ROC.
C-P Yang
D-T Lin
I-J Hung
K-H Lin
J-S Chen
C-C Hsiao
T-T Chang
C-T Peng
M-T Lin
T-K Chang
T-H Jaing
H-C Liu
L-Y Wang
T-C Yeh
S-T Jou
M-Y Lu
C-N Cheng
J-M Sheen
S-S Chiou
K-H Wu
G-Y Hung
R-L Chen
S-H Chen
S-N Cheng
Y-H Chang
B-W Chen
W-L Ho
J-L Wang
S-T Lin
Y-L Hsieh
S-C Wang
H-H Chang
Y-L Yang
F-L Huang
C-Y Chang
W-H Chang
K-S Lin
National Taiwan University Hospital · TWChang Gung Children's Hospital · TWMackay Memorial Hospital · TWChanghua Christian Hospital · TWChina Medical University Hospital · TWKaohsiung Medical University Chung-Ho Memorial Hospital · TWNational Cheng Kung University Hospital · TWTaichung Veterans General Hospital · TWTaipei Medical University Hospital · TWBuddhist Tzu Chi General Hospital · TWCathay General Hospital · TWChi Mei Medical Center · TWKaohsiung Veterans General Hospital · TWKoo Foundation Sun Yat-Sen Cancer Center · TWTaipei Medical University · TWTaipei Veterans General Hospital · TWTri-Service General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The long-term outcome of 1390 children with acute lymphoblastic leukemia (ALL), treated in two successive clinical trials (Taiwan Pediatric Oncology Group (TPOG)-ALL-97 and TPOG-ALL-2002) between 1997 and 2007, is reported. The event-free survival improved significantly (P=0.0004) over this period, 69.3+/-1.9% in 1997-2001 to 77.4+/-1.7% in 2002-2007. A randomized trial in TPOG-97 testing L-asparaginase versus epidoxorubicin in combination with vincristine and prednisolone for remission induction in standard-risk (SR; low-risk) patients yielded similar outcomes. Another randomized trial, in TPOG-2002, showed that for SR patients, two reinduction courses did not improve long-term outcome over one course. Decreasing use of prophylactic cranial irradiation in the period 1997-2008 was not associated with increased rates of CNS relapse, prompting complete omission of prophylactic cranial irradiation from TPOG protocols, beginning in 2009. Decreased use of etoposide and cranial irradiation likely contributed to the low incidence of second cancers. High-risk B-lineage ALL, T-cell, CD10 negativity, t(9;22), infant, and higher leukocyte count were consistently adverse factors, whereas hyperdiploidy >50 was a consistently favorable factor. Higher leukocyte count and t(9;22) retained prognostic significance in both TPOG-97 and TPOG-2002 by multivariate analysis. Although long-term outcome in TPOG clinical trials is comparable with results being reported worldwide, the persistent strength of certain prognostic variables and the lower frequencies of favorable outcome predictors, such as ETV6-RUNX1 and hyperdiploidy >50, in Taiwanese children warrant renewed effort to cure a higher proportion of patients while preserving their quality of life.

Indexed as

AdolescentAntineoplastic Combined Chemotherapy ProtocolsChildChild, PreschoolChromosome AberrationsCombined Modality TherapyCranial IrradiationFemaleFollow-Up StudiesHumansImmunophenotypingInfantMaleNeoplasm Recurrence, LocalNeoplasm, ResidualNeoplasms, Second Primary

Identifiers

PMID20016538
OpenAlexW2061418833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.