ArticleJournal of human hypertension2010
Identical pattern of cerebral hypoperfusion during different types of syncope.
Article in Journal of human hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Impact of hypocapnia and cerebral perfusion on orthostatic tolerance.The Journal of physiology · 2014Trial
- The pathophysiology of the vasovagal response.Heart rhythm · 2018Review
- Transcranial Doppler in autonomic testing: standards and clinical applications.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Significant role of the cardiopostural interaction in blood pressure regulation during standing.American journal of physiology. Heart and circulatory physiology · 2017Article
- Cerebral blood flow during HUTT in young patients with orthostatic intolerance.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2015Article
- Autonomic cardiovascular response to acute hypoxia and passive head-up tilting in humans.European journal of applied physiology · 2013Article
- "He's dizzy when he stands up": an introduction to initial orthostatic hypotension.The Journal of pediatrics · 2011Article
- Role of SNA in the pathophysiology of cardiovascular collapse during syncope: muscle vs. brain.The Journal of physiology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syncope is caused by insufficient oxygen supply to the brain. There have been attempts to classify syncope on the basis of defects in the venous system, arterial system (that is impaired systemic vascular resistance) or a combination of the two (that is mixed). We examined the hypothesis that a comparable decrease in cerebral perfusion would be evident at pre-syncope irrespective of the category of dysfunction. Young healthy volunteers (N=37) participated. The protocol consisted of 15 min supine rest, followed by 60 degrees head-up tilt and lower body suction in increments of -10 mm Hg for 5 min each until pre-syncope. Beat-to-beat blood pressure (BP) (Finometer or intra-arterial), cardiac output (Finometer), middle cerebral artery blood velocity (MCAv), end-tidal CO(2) and cerebral oxygenation were monitored continuously. At pre-syncope, mixed dysfunction was common (21 out of 37 participants), followed by venular dysfunction (15 out of 37 participants). In the venular and mixed groups, comparable orthostatic tolerance and declines in BP (-37 vs -43% from baseline, respectively), end-tidal PCO(2), MCAv (-35 vs -38%) and cerebral oxygenation (-5 vs -7%) were evident despite distinct mechanisms purportedly being responsible for the hypotension. Although different determinants of hypotension do exist, cerebral hypoperfusion occurs to a similar extent.
Indexed as
Identifiers
20016525What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.