Evidence map›Paper›PMID 20016506›Full record

ReviewNature immunology2010

Mechanisms maintaining peripheral tolerance.

Daniel L Mueller

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

206 citing papers in PubMed.

  1. Review
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  17. Review
  18. Immunomodulation by allograft endothelial cells.Frontiers in transplantation · 2025
    Review
  19. Review
  20. Article

146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Daniel L MuellerDepartment of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA. muell002@umn.edu

Funding

Type I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JENKINS, MARC KEVIN · 1993 to 2023
$31.1M
Epigenetic Control of T cell AutoimmunityR01AI080764 · NIAID · UNIVERSITY OF MINNESOTA · PI MUELLER, DANIEL L · 2009 to 2010
$755k
NIAID NIH HHS P01 AI035296NIAID NIH HHS P01 AI35296NIAID NIH HHS R01 AI080764
6 · The paper itself

Abstract

The presentation of self-peptide-MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an important problem to the immune system. In this review, I discuss data that reveal barriers preventing peripheral T cell recognition of self-peptide-MHC complexes, as well as the physiological mechanisms that ensure the elimination or functional inactivation (anergy) of T cells that do come to recognize self-peptide-MHC and threaten the health of the individual.

Indexed as

AnimalsAntigen PresentationApoptosisDendritic CellsHumansImmune ToleranceMajor Histocompatibility ComplexModels, ImmunologicalReceptors, Antigen, T-CellT-LymphocytesReceptors, Antigen, T-Cell

Identifiers

PMID20016506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.