ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Novel mediators of amyloid precursor protein signaling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- The Hippo signaling pathway as a therapeutic target in Alzheimer's disease.Molecular neurodegeneration · 2025Review
- The Physiological and Pathological Mechanisms of LIN2, LIN7, LIN10 and Their Tripartite Complex.Journal of cellular and molecular medicine · 2025Review
- Article
- Review
- Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer.International journal of molecular sciences · 2021Review
- LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7.Molecular biology of the cell · 2021Article
- Golgi localization of the LIN-2/7/10 complex points to a role in basolateral secretion of LET-23 EGFR in theDevelopment (Cambridge, England) · 2021Article
- Panoramic Visualization of Circulating MicroRNAs Across Neurodegenerative Diseases in Humans.Molecular neurobiology · 2019Article
- Disease implication of hyper-Hippo signalling.Open biology · 2016Review
- Review
- Dynamic self-guiding analysis of Alzheimer's disease.Oncotarget · 2015Review
- Paradoxical effect of TrkA inhibition in Alzheimer's disease models.Journal of Alzheimer's disease : JAD · 2014Article
- AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease.Journal of Alzheimer's disease : JAD · 2013Article
- Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder.PloS one · 2013Article
- Characterization of amyloid-β precursor protein intracellular domain-associated transcriptional complexes in SH-SY5Y neurocytes.Neuroscience bulletin · 2012Article
- A new role for laminins as modulators of protein toxicity in Caenorhabditis elegans.Aging cell · 2012Article
- Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex.BMC genomics · 2011Article
- Article
- A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Multiple recent reports implicate amyloid precursor protein (APP) signaling in the pathogenesis of Alzheimer's disease, but the APP-dependent signaling network involved has not been defined. Here, we report a novel consensus sequence for interaction with the PDZ-1 and PDZ-2 domains of the APP-interacting proteins Mint1, Mint2, and Mint3 (X11alpha, X11beta, and X11gamma), and multiple novel interactors for these proteins, with the finding that transcriptional coactivators are highly represented among these interactors. Furthermore, we show that Mint3 interaction with a set of the transcriptional coactivators leads to nuclear localization and transactivation, whereas interaction of the same set with Mint1 or Mint2 prevents nuclear localization and transactivation. These results define new mediators of the signal transduction network mediated by APP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.