ArticleJournal of cell science2010
Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Extracellular matrix: Dystroglycan interactions-Roles for the dystrophin-associated glycoprotein complex in skeletal tissue dynamics.International journal of experimental pathology · 2025Review
- Article
- The Role of β-Dystroglycan in Nuclear Dynamics.Cells · 2024Article
- Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability.International journal of molecular sciences · 2020Article
- Retrograde trafficking of β-dystroglycan from the plasma membrane to the nucleus.Scientific reports · 2017Article
- HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures.Cell communication and signaling : CCS · 2017Article
- Promoting differentiation of cultured myoblasts using biomimetic surfaces that present alpha-laminin-2 peptides.Cytotechnology · 2016Article
- γ-Secretase Dependent Nuclear Targeting of Dystroglycan.Journal of cellular biochemistry · 2016Article
- CD93 and dystroglycan cooperation in human endothelial cell adhesion and migration adhesion and migration.Oncotarget · 2016Article
- Article
- Dystroglycan Depletion Impairs Actin-Dependent Functions of Differentiated Kasumi-1 Cells.PloS one · 2015Article
- Nuclear import of β-dystroglycan is facilitated by ezrin-mediated cytoskeleton reorganization.PloS one · 2014Article
- Modulation of dorsal root ganglion development by ErbB signaling and the scaffold protein Sorbs3.Development (Cambridge, England) · 2013Article
- Nuclear targeting of dystroglycan promotes the expression of androgen regulated transcription factors in prostate cancer.Scientific reports · 2013Article
- Focal adhesion size uniquely predicts cell migration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse.Human molecular genetics · 2012Article
- Insertion of a myc-tag within α-dystroglycan domains improves its biochemical and microscopic detection.BMC biochemistry · 2012Article
- Dystrophin Dp71: the smallest but multifunctional product of the Duchenne muscular dystrophy gene.Molecular neurobiology · 2012Review
- Depletion of the actin bundling protein SM22/transgelin increases actin dynamics and enhances the tumourigenic phenotypes of cells.BMC cell biology · 2012Article
- Polarization and myelination in myelinating glia.ISRN neurology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Dystroglycan is a ubiquitously expressed cell adhesion protein. Its principal role has been determined as a component of the dystrophin-glycoprotein complex of muscle, where it constitutes a key component of the costameric cell adhesion system. To investigate more fundamental aspects of dystroglycan function in cell adhesion, we examined the role of dystroglycan in the dynamics and assembly of cellular adhesions in myoblasts. We show that beta-dystroglycan is recruited to adhesion structures and, based on staining for vinculin, that overexpression or depletion of dystroglycan affects both size and number of fibrillar adhesions. Knockdown of dystroglycan increases the size and number of adhesions, whereas overexpression decreases the number of adhesions. Dystroglycan knockdown or overexpression affects the ability of cells to adhere to different substrates, and has effects on cell migration that are consistent with effects on the formation of fibrillar adhesions. Using an SH3 domain proteomic screen, we identified vinexin as a binding partner for dystroglycan. Furthermore, we show that dystroglycan can interact indirectly with vinculin by binding to the vinculin-binding protein vinexin, and that this interaction has a role in dystroglycan-mediated cell adhesion and spreading. For the first time, we also demonstrate unequivocally that beta-dystroglycan is a resident of focal adhesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.