ArticleThe Journal of clinical endocrinology and metabolism2010
Adipokine profile and urinary albumin excretion in isolated growth hormone deficiency.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Relationship of adiponectin to endogenous GH pulse secretion parameters in response to stimulation with a growth hormone releasing factor.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2011Trial
- Effects of growth hormone-releasing hormone deficiency in mice beyond growth.Reviews in endocrine & metabolic disorders · 2025Review
- Comparative Analysis of the GH/IGF-1 Axis during the First Sixth Months in Children with Low Birth Weight.Children (Basel, Switzerland) · 2023Article
- The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome.Archives of endocrinology and metabolism · 2022Review
- Reduced fibroblast growth factor 21 and β-Klotho secretion in untreated congenital isolated GH deficiency.Endocrine · 2021Article
- Article
- Disruption of the GHRH receptor and its impact on children and adults: The Itabaianinha syndrome.Reviews in endocrine & metabolic disorders · 2021Review
- Article
- Growth Hormone Deficiency: Health and Longevity.Endocrine reviews · 2019Review
- Relationship between IGF-I Concentration and Metabolic Profile in Children with Growth Hormone Deficiency: The Influence of Children's Nutritional State as well as the Ghrelin, Leptin, Adiponectin, and Resistin Serum Concentrations.International journal of endocrinology · 2017Article
- Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis.Endocrine connections · 2016Article
- GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity.The Journal of clinical endocrinology and metabolism · 2015Article
- Article
- Liver status in congenital, untreated, isolated GH deficiency.Endocrine connections · 2014Article
- Article
- Somatotropic signaling: trade-offs between growth, reproductive development, and longevity.Physiological reviews · 2013Review
- The consequences of growth hormone-releasing hormone receptor haploinsufficiency for bone quality and insulin resistance.Clinical endocrinology · 2012Article
- Growth factors, nutrient signaling, and cardiovascular aging.Circulation research · 2012Review
- Pleiotropic effects of growth hormone signaling in aging.Trends in endocrinology and metabolism: TEM · 2011Review
- Growth hormone and adipose tissue: beyond the adipocyte.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundGH deficiency (GHD) is often associated with cardiovascular risk factors, including abdominal fat accumulation, hypercholesterolemia, and increased C-reactive protein. Despite the presence of these risk factors, adults with congenital lifetime isolated GHD (IGHD) due to an inactivating mutation in the GHRH receptor gene do not have premature atherosclerosis.
objectiveThe aim was to study the serum levels of adiponectin and leptin (antiatherogenic and atherogenic adipokine, respectively), and the urinary albumin excretion (UAE) in these IGHD individuals. DESIGN AND PATIENTS: We conducted a cross-sectional study of 20 IGHD individuals (seven males; age, 50.8 +/- 14.6 yr) and 22 control subjects (eight males; age, 49.9 +/- 11.5 yr).
main outcome measuresAnthropometric factors, body composition, blood pressure, serum adiponectin, leptin, and UAE were measured.
resultsAdiponectin was higher [12.8 (7.1) vs. 9.7 (5) ng/ml; P = 0.041] in IGHD subjects, whereas no difference was observed in leptin [7.3 (6.3) vs. 9.3 (18.7 ng/ml] and UAE [8.6 (13.8) vs. 8.5 (11.1) microg/min].
conclusionsSubjects with lifetime untreated IGHD have an adipokine profile with high adiponectin and normal leptin levels that may delay vascular damage and lesions of the renal endothelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.