ArticleClinical and vaccine immunology : CVI2010
Cellular immune responses of preterm infants after vaccination with whole-cell or acellular pertussis vaccines.
Article in Clinical and vaccine immunology : CVI, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Acellular pertussis booster in adolescents induces Th1 and memory CD8+ T cell immune response.PloS one · 2011Trial
- Pertussis-A Re-Emerging Threat Despite Immunization: An Analysis of Vaccine Effectiveness and Antibiotic Resistance.International journal of molecular sciences · 2025Review
- Comparative Evaluation of Recombinant and Acellular Pertussis Vaccines in a Murine Model.Vaccines · 2024Article
- Immunogenicity of a new enhanced tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccine against Bordetella pertussis in a murine model.BMC immunology · 2021Article
- Vaccine-Induced Cellular Immunity againstVaccines · 2021Review
- ReducedFrontiers in aging · 2021Article
- Assessment of humoral and cell-mediated immune responses to pertussis vaccination: a systematic review protocol.BMJ open · 2019Article
- AhR Activation by TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) Attenuates Pertussis Toxin-Induced Inflammatory Responses by Differential Regulation of Tregs and Th17 Cells Through Specific Targeting by microRNA.Frontiers in microbiology · 2019Article
- Persistence of Vaccine-Induced Immunity in Preschool Children: Effect of Gestational Age.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Molecular and cellular signatures underlying superior immunity against Bordetella pertussis upon pulmonary vaccination.Mucosal immunology · 2018Article
- What Is Wrong with Pertussis Vaccine Immunity? Why Immunological Memory to Pertussis Is Failing.Cold Spring Harbor perspectives in biology · 2017Review
- Pertussis: Microbiology, Disease, Treatment, and Prevention.Clinical microbiology reviews · 2016Review
- Transcriptome signature for dampened Th2 dominance in acellular pertussis vaccine-induced CD4(+) T cell responses through TLR4 ligation.Scientific reports · 2016Article
- Waning and aging of cellular immunity to Bordetella pertussis.Pathogens and disease · 2015Review
- Roads to the development of improved pertussis vaccines paved by immunology.Pathogens and disease · 2015Review
- Underweight full-term Indian neonates show differences in umbilical cord blood leukocyte phenotype: a cross-sectional study.PloS one · 2015Article
- Bordetella pertussis proteins dominating the major histocompatibility complex class II-presented epitope repertoire in human monocyte-derived dendritic cells.Clinical and vaccine immunology : CVI · 2014Article
- Bordetella pertussis pathogenesis: current and future challenges.Nature reviews. Microbiology · 2014Review
- Loss of multi-epitope specificity in memory CD4(+) T cell responses to B. pertussis with age.PloS one · 2013Observational
- Both CD4⁺ and CD8⁺ lymphocytes participate in the IFN-γ response to filamentous hemagglutinin from Bordetella pertussis in infants, children, and adults.Clinical & developmental immunology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on studies reporting specific antibody titers, it is recommended to vaccinate preterm infants against Bordetella pertussis according to their chronological age. However, as specific T-cell responses also are involved in the protection against B. pertussis, we have determined whether highly preterm infants (<31 weeks) are able to mount these immune responses during vaccination. Forty-eight premature infants were vaccinated at 2, 3, and 4 months of their chronological age with an acellular (Pa; n = 24) or a whole-cell (Pw; n = 24) tetravalent diphtheria-tetanus-pertussis-polio vaccine, and blood samples were collected at 2, 3, and 6 months of age. Most of the Pa- and Pw-vaccinated infants developed at 3 or 6 months of age a gamma interferon (IFN-gamma) response to the B. pertussis antigens, accompanied by an interleukin-5 (IL-5) and IL-13 secretion for the Pa-vaccinated infants. No association was found between a very low infant birth weight, the occurrence of severe infections, and corticosteroid treatment or the administration of gammaglobulins with a low level of antigen-induced IFN-gamma secretion. We conclude that like full-term infants, most preterm infants are able to mount a specific cellular immune response to the administration of the first doses of an acellular or a whole-cell pertussis vaccine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.