ArticleJournal of virology2010
Regulation of porcine endogenous retrovirus release by porcine and human tetherins.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Surveillance and prevention of infection in clinical xenotransplantation.Clinical microbiology reviews · 2025Review
- Role of Type I Interferons duringBiomolecules · 2024Review
- Review
- Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?Retrovirology · 2018Review
- The effect of bovine BST2A1 on the release and cell-to-cell transmission of retroviruses.Virology journal · 2017Article
- How Active Are Porcine Endogenous Retroviruses (PERVs)?Viruses · 2016Review
- Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein.Journal of virology · 2014Article
- Epitope tags beside the N-terminal cytoplasmic tail of human BST-2 alter its intracellular trafficking and HIV-1 restriction.PloS one · 2014Article
- Functional antagonism of rhesus macaque and chimpanzee BST-2 by HIV-1 Vpu is mediated by cytoplasmic domain interactions.Journal of virology · 2013Article
- Role of DNA methylation in expression and transmission of porcine endogenous retroviruses.Journal of virology · 2013Article
- Identification and promoter analysis of PERV LTR subtypes in NIH-miniature pig.Molecules and cells · 2013Article
- Vpu binds directly to tetherin and displaces it from nascent virions.PLoS pathogens · 2013Article
- A new approach to establish a cell line with reduced risk of endogenous retroviruses.PloS one · 2013Article
- Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses.Clinical microbiology reviews · 2012Review
- Article
- Article
- Identification of Residues in the BST-2 TM Domain Important for Antagonism by HIV-1 Vpu Using a Gain-of-Function Approach.Frontiers in microbiology · 2011Article
- The interferon-inducible host factor bone marrow stromal antigen 2/tetherin restricts virion release, but is it actually a viral restriction factor?Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2011Review
- Suboptimal porcine endogenous retrovirus infection in non-human primate cells: implication for preclinical xenotransplantation.PloS one · 2010Article
- Retroviral restriction factors and infectious risk in xenotransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk of transmission of porcine endogenous retrovirus (PERV) is one of the major safety issues in xenotransplantation. Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine homologue were shown to inhibit PERV release from producer cells, establishing themselves as candidate molecules to suppress PERV production in porcine xenografts by animal engineering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.