ArticleHuman molecular genetics2010
European lactase persistence genotype shows evidence of association with increase in body mass index.
Article in Human molecular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals.International journal of obesity (2005) · 2021Pooled it
- Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis.International journal of epidemiology · 2016Pooled it
- Circulating thrifty microRNA is related to insulin sensitivity, adiposity, and energy metabolism in adults with overweight and obesity: the POUNDS Lost trial.The American journal of clinical nutrition · 2023Trial
- Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial.International journal of obesity (2005) · 2018Trial
- A positively selected microRNA controls a reversible aging program in striated muscle.bioRxiv : the preprint server for biology · 2026Article
- MCM proteins are up-regulated in placentas of women with reduced insulin sensitivity.Bioscience reports · 2024Article
- Longitudinal prospective anthropometric evaluation in Caucasian prepubertal children with lactose intolerance.Frontiers in pediatrics · 2023Article
- Anthropometric and metabolic profile of children with gene polymorphisms for primary lactose intolerance.Experimental and therapeutic medicine · 2021Article
- MicroRNA-mediated regulation of glucose and lipid metabolism.Nature reviews. Molecular cell biology · 2021Review
- Article
- Evolution of Lactase Persistence: Turbo-Charging Adaptation in Growth Under the Selective Pressure of Maternal Mortality?Frontiers in physiology · 2021Article
- Article
- Clinical Utility ofNutrients · 2020Observational
- Adaptation to milking agropastoralism in Chilean goat herders and nutritional benefit of lactase persistence.Annals of human genetics · 2019Article
- Review
- The lactase -13910C>T polymorphism (rs4988235) is associated with overweight/obesity and obesity-related variables in a population sample of Portuguese young adults.European journal of clinical nutrition · 2017Article
- Hypolactasia is associated with insulin resistance in nonalcoholic steatohepatitis.World journal of hepatology · 2016Article
- Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.Molecular genetics and genomics : MGG · 2015Review
- Adult lactose digestion status and effects on disease.Canadian journal of gastroenterology & hepatology · 2015Review
- The lactase persistence genotype is a protective factor for the metabolic syndrome.Genetics and molecular biology · 2014Article
Corrections and comments
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Authors and funding
27 authors at 13 institutions in 5 countries.
Funding
Abstract
The global prevalence of obesity has increased significantly in recent decades, mainly due to excess calorie intake and increasingly sedentary lifestyle. Here, we test the association between obesity measured by body mass index (BMI) and one of the best-known genetic variants showing strong selective pressure: the functional variant in the cis-regulatory element of the lactase gene. We tested this variant since it is presumed to provide nutritional advantage in specific physical and cultural environments. We genetically defined lactase persistence (LP) in 31 720 individuals from eight European population-based studies and one family study by genotyping or imputing the European LP variant (rs4988235). We performed a meta-analysis by pooling the beta-coefficient estimates of the relationship between rs4988235 and BMI from the nine studies and found that the carriers of the allele responsible for LP among Europeans showed higher BMI (P = 7.9 x 10(-5)). Since this locus has been shown to be prone to population stratification, we paid special attention to reveal any population substructure which might be responsible for the association signal. The best evidence of exclusion of stratification came from the Dutch family sample which is robust for stratification. In this study, we highlight issues in model selection in the genome-wide association studies and problems in imputation of these special genomic regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.