ArticleBehavioural brain research2010
Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging.
Article in Behavioural brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Pesticide exposure and neurodevelopmental outcomes: review of the epidemiologic and animal studies.Journal of toxicology and environmental health. Part B, Critical reviews · 2013Pooled it
- Persisting neurobehavioral consequences of daily or intermittent paternal cannabis administration in F1 and F2 Rats.Neurotoxicology · 2024Article
- Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development.The Science of the total environment · 2024Article
- The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides.Archives of toxicology · 2023Review
- The Association between Pesticide Exposure and the Development of Fronto-Temporal Dementia-Cum-Dissociative Disorders: A Review.Brain sciences · 2023Review
- The mechanistic basis for the toxicity difference between juvenile rats and mice following exposure to the agricultural insecticide chlorpyrifos.Toxicology · 2022Article
- Persistent neurobehavioral and neurochemical anomalies in middle-aged rats after maternal diazinon exposure.Toxicology · 2022Article
- A critical role for GM1 ganglioside in the pathophysiology and potential treatment of Parkinson's disease.Glycoconjugate journal · 2022Review
- Inhibition of Serum Esterases in Juvenile Rats Repeatedly Exposed to Low Levels of Chlorpyrifos.International journal of scientific research in environmental science and toxicology · 2022Article
- Neurotoxicity in acute and repeated organophosphate exposure.Toxicology · 2018Review
- Critical developmental periods for effects of low-level tobacco smoke exposure on behavioral performance.Neurotoxicology · 2018Article
- Prenatal Organophosphate Pesticide Exposure and Traits Related to Autism Spectrum Disorders in a Population Living in Proximity to Agriculture.Environmental health perspectives · 2018Article
- Sex-Specific Neurotoxic Effects of Organophosphate Pesticides Across the Life Course.Current environmental health reports · 2017Review
- Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms.Journal of neurochemistry · 2017Review
- Urinary organophosphate insecticide metabolite concentrations during pregnancy and children's interpersonal, communication, repetitive, and stereotypic behaviors at 8 years of age: The home study.Environmental research · 2017Article
- Diazinon and parathion diverge in their effects on development of noradrenergic systems.Brain research bulletin · 2017Article
- Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure?Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Role of the calcium plateau in neuronal injury and behavioral morbidities following organophosphate intoxication.Annals of the New York Academy of Sciences · 2016Review
- Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes.Brain research · 2016Article
- A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Developmental exposure of rats to the organophosphate (OP) pesticides leads to altered neurobehavioral function in juvenile and young adult stages. The current study was conducted to determine whether effects of neonatal parathion exposure on cognitive performance persist in older adult and aged rats, and the relationship of behavioral changes to underlying cholinergic and serotonergic mechanisms. We administered parathion to rat pups on postnatal days 1-4, at doses spanning the threshold for the initial signs of systemic toxicity and for barely detectable cholinesterase inhibition (0.1 or 0.2 mg/kg/day). Beginning at 14 months of age and continuing until 19 months, the rats were trained in the 16-arm radial maze. Controls showed the normal sex difference in this spatial learning and memory task, with the males committing significantly fewer working memory errors than females. Neonatal parathion exposure eliminated the sex difference primarily by causing impairment in males. In association with the effects on cognitive performance, neonatal parathion exposure elicited widespread abnormalities in indices of serotonergic (5HT) and cholinergic synaptic function, characterized by upregulation of 5HT(2) receptors and the 5HT transporter, deficits in choline acetyltransferase activity and nicotinic cholinergic receptors, and increases in hemicholinium-3 binding to the presynaptic choline transporter. Within-animal correlations between behavior and neurochemistry indicated a specific correlation between working memory performance and hippocampal hemicholinium-3 binding; parathion exposure eliminated this relationship. Like the behavioral effects, males showed greater effects of parathion on neurochemical parameters. This study demonstrates the sex-selective, long-term behavioral alterations caused by otherwise nontoxic neonatal exposure to parathion, with effects increasingly expressed with aging.
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