Evidence map›Paper›PMID 20015358›Full record

Trial reportArthritis research & therapy2009

Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial.

Alain Jacquet, Pierre-Olivier Girodet, Antoine Pariente, Karelle Forest, Laurent Mallet, Nicholas Moore

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arthritis research & therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00666523 (Randomized Double-Blind Study of Food Supplement Phytalgic on Symptoms of Osteoarthritis), which is not on this map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00666523 nacompletednot on this map

Randomized Double-Blind Study of Food Supplement Phytalgic on Symptoms of Osteoarthritis

TypeinterventionalSponsorUniversité Victor Segalen Bordeaux 2Ran2007 to 2008Enrolled81ConditionsOsteoarthritisArmsphytalgic, placebo
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  5. Oral herbal therapies for treating osteoarthritis.The Cochrane database of systematic reviews · 2014
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alain JacquetDepartment of Pharmacology, University of Bordeaux, 146 rue Léo Saignat, 33076, Bordeaux, France. docteur.alain.jacquet@wanadoo.fr
Pierre-Olivier Girodet
Antoine Pariente
Karelle Forest
Laurent Mallet
Nicholas Moore
Université de Bordeaux · FRCentre d'Investigation Clinique - Innovation Technologique · FRCIC Rennes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe medicinal treatment of osteoarthritis (OA) is mostly symptomatic to relieve pain and incapacity with analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), drugs with well-known risks. Complementary medicines might reduce the symptoms of OA and decrease the need for NSAIDs. This study tested the effects of a food supplement, Phytalgic, on pain and function in patients with osteoarthritis and their use of analgesic and NSAIDs.

methodsA randomized double-blind parallel-groups clinical trial compared Phytalgic (fish-oil, vitamin E, Urtica dioica) to a placebo for three months, in 81 patients with OA of the knee or hip using NSAIDs and/or analgesics regularly. The main outcome measures were use of NSAIDs (in Defined Daily Doses per day - DDD/day) or analgesics (in 500 mg paracetamol-equivalent tablets per week (PET/week) measured each month, and Western Ontario-McMaster University Osteo-Arthritis Index (WOMAC) function scales.

resultsAfter three months of treatment, the mean use of analgesics in the active arm (6.5 PET/week) vs. the placebo arm (16.5) was significantly different (P < 0.001) with a group mean difference of -10.0 (95% CI: -4.9 to -15.1). That of NSAIDs in the active arm (0.4 DDD/day) vs the placebo arm (1.0 DDD/day) was significantly different (P = 0.02) with a group mean difference of - 0.7 DDD/day (95% CI: -0.2 to -1.2). Mean WOMAC scores for pain, stiffness and function in the active arm (respectively 86.5, 41.4 and 301.6) vs the placebo arm (resp. 235.3, 96.3 and 746.5) were significantly different (P < 0.001) with group mean differences respectively of -148.8 (95% CI: -97.7 to -199.9), -54.9 (95% CI: -27.9 to -81.9) and -444.8 (95% CI: -269.1 to -620.4).

conclusionsThe food supplement tested appeared to decrease the need for analgesics and NSAIDs and improve the symptoms of osteoarthritis.

trial registrationClinicaltrials.gov NCT00666523.

Indexed as

Dietary SupplementsPhytotherapyAcetaminophenAdultAgedAnalgesicsAnti-Inflammatory Agents, Non-SteroidalDouble-Blind MethodFemaleFish OilsHumansMaleMiddle AgedOsteoarthritisPainPlacebosAcetaminophenAnalgesicsAnti-Inflammatory Agents, Non-SteroidalFish OilsPlacebosVitamin E

Identifiers

PMID20015358
PMCPMC3003499
OpenAlexW2163038972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.