ArticleGenes, brain, and behavior2010
Genetic disruptions of Drosophila Pavlovian learning leave extinction learning intact.
Article in Genes, brain, and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Genomes from historical Drosophila melanogaster specimens illuminate adaptive and demographic changes across more than 200 years of evolution.PLoS biology · 2023Article
- Neural Circuits Underlying Behavioral Flexibility: Insights FromFrontiers in behavioral neuroscience · 2021Review
- NewG3 (Bethesda, Md.) · 2019Article
- Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies.Nature communications · 2016Article
- Candidate genes for individual recognition in Polistes fuscatus paper wasps.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Conditioned avoidance responses survive contingency degradation in the garden slug, Lehmannia valentiana.Learning & behavior · 2014Article
- Social regulation of maternal traits in nest-founding bumble bee (Bombus terrestris) queens.The Journal of experimental biology · 2013Article
- Long-term enhancement of synaptic transmission between antennal lobe and mushroom body in cultured Drosophila brain.The Journal of physiology · 2013Article
- Aversive olfactory learning and associative long-term memory in Caenorhabditis elegans.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Second-order conditioning in Drosophila.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Memory formation in reversal learning of the honeybee.Frontiers in behavioral neuroscience · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Individuals who experience traumatic events may develop persistent posttraumatic stress disorder. Patients with this disorder are commonly treated with exposure therapy, which has had limited long-term success. In experimental neurobiology, fear extinction is a model for exposure therapy. In this behavioral paradigm, animals are repeatedly exposed in a safe environment to the fearful stimulus, which leads to greatly reduced fear. Studying animal models of extinction already has lead to better therapeutic strategies and development of new candidate drugs. Lack of a powerful genetic model of extinction, however, has limited progress in identifying underlying molecular and genetic factors. In this study, we established a robust behavioral paradigm to study the short-term effect (acquisition) of extinction in Drosophila melanogaster. We focused on the extinction of olfactory aversive 1-day memory with a task that has been the main workhorse for genetics of memory in flies. Using this paradigm, we show that extinction can inhibit each of two genetically distinct forms of consolidated memory. We then used a series of single-gene mutants with known impact on associative learning to examine the effects on extinction. We find that extinction is intact in each of these mutants, suggesting that extinction learning relies on different molecular mechanisms than does Pavlovian learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.