ArticleJournal of cellular and molecular medicine2011
Expression of NPP1 is regulated during atheromatous plaque calcification.
Article in Journal of cellular and molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- ENPP1 Immunobiology as a Therapeutic Target.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Review
- Biomolecules Orchestrating Cardiovascular Calcification.Biomolecules · 2021Review
- ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors-A STING in the Tale of ENPP1.Molecules (Basel, Switzerland) · 2019Review
- Calcium Signaling and Tissue Calcification.Cold Spring Harbor perspectives in biology · 2019Review
- Review
- Article
- Regulatory circuits controlling vascular cell calcification.Cellular and molecular life sciences : CMLS · 2013Review
- Role of CD73 and extracellular adenosine in disease : Presented by Maria P. Abbracchio.Purinergic signalling · 2011Article
- Npp1 promotes atherosclerosis in ApoE knockout mice.Journal of cellular and molecular medicine · 2011Article
- Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel.Circulation research · 2011Review
- Key role of alkaline phosphatase in the development of human-derived nanoparticles in vitro.Acta biomaterialia · 2011Article
- Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations of the ENPP1 gene encoding ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) are associated with medial calcification in infancy. While the inhibitory role of matrix proteins such as osteopontin (OPN) with respect to atherosclerotic plaque calcification has been established, the role of NPP1 in plaque calcification is not known. We assessed the degree of plaque calcification (computed tomography), NPP1 and OPN localization (immunohistochemistry) and expression (RT-PCR) in a cohort of 45 patients undergoing carotid endatherectomy for significant stenosis of the internal carotid artery and in normal arteries (N= 50). We correlated NPP1 and OPN expression levels to the degree of plaque calcification, to pro-atherogenic factors and statin therapy. NPP1 was demonstrated in the base and in the shoulder of atherosclerotic plaques. Compared to normal arteries and non-calcified plaques, in calcified plaques NPP1 mRNA was decreased (P < 0.0001). OPN mRNA levels were up-regulated in carotid atheroma. NPP1 and OPN expression levels positively correlated with the degree of plaque calcification (R= 0.54, P= 0.00019 and R= 0.46, P= 0.017, respectively) and with risk factors of atherosclerosis. Expression of the calcification inhibitor NPP1 is down-regulated in calcified atherosclerotic plaques. Our correlation data point to a counter-active mechanism, which in the end turns out to be insufficient to prevent further progression of calcification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.