ArticleThe American journal of drug and alcohol abuse2009
Characteristics of opioid-using pregnant women who accept or refuse participation in a clinical trial: screening results from the MOTHER study.
Article in The American journal of drug and alcohol abuse, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03098407 (A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.), which is not on this map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Access to Medications for Opioid Use Disorder and Associated Factors Among Adolescents and Young Adults: A Systematic Review.JAMA pediatrics · 2022Pooled it
- Non-pharmacological care for opioid withdrawal in newborns.The Cochrane database of systematic reviews · 2020Pooled it
- Maintenance agonist treatments for opiate-dependent pregnant women.The Cochrane database of systematic reviews · 2020Pooled it
- Influence of site differences between urban and rural American and Central European opioid-dependent pregnant women and neonatal outcome characteristics.European addiction research · 2012Trial
- Are male neonates more vulnerable to neonatal abstinence syndrome than female neonates?Gender medicine · 2011Trial
- Randomized controlled trials in pregnancy: scientific and ethical aspects. Exposure to different opioid medications during pregnancy in an intra-individual comparison.Addiction (Abingdon, England) · 2011Trial
- Neonatal abstinence syndrome after methadone or buprenorphine exposure.The New England journal of medicine · 2010Trial
- Prevalence of alcohol use in pregnant women with substance use disorder.Drug and alcohol dependence · 2018Article
- Non-medical opioid use and sources of opioids among pregnant and non-pregnant reproductive-aged women.Drug and alcohol dependence · 2017Article
- Increasing pregnancy-related use of prescribed opioid analgesics.Annals of epidemiology · 2013Article
- The treatment of alcohol and opioid dependence in pregnant women.Current opinion in psychiatry · 2012Review
- Pharmacologic management of the opioid neonatal abstinence syndrome.Pediatric clinics of North America · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundAlthough concerns arise about the generalizability of results from Randomized Controlled Trials (RCTs), few studies systematically examine this issue.
objectivesThis study compared the characteristics of 427 opioid-using pregnant women who did (n = 208) and did not consent (n = 219) to enrollment in a multicenter clinical trial of agonist medications (i.e., the MOTHER study).
methodsLogistic regression models were used to compare consenters and non-consenters to examine the effect of screening variables on the likelihood of consenting.
resultsOf nine characteristics examined, most differences did not reach statistical significance. Consenting participants were less likely than non-consenting women to be currently enrolled in a methadone maintenance program (74.5% vs. 84.5%, p =.01). CONCLUSION AND SCIENTIFIC SIGNIFICANCE: These data show that the recruited sample of drug-dependent pregnant women enrolled in an intensive RCT is representative of the larger population of treated opioid-dependent patients and supports the generalizability of randomized controlled trials in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.