ReviewDevelopmental disabilities research reviews2009
Treatments for fragile X syndrome: a closer look at the data.
Review in Developmental disabilities research reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- L-acetylcarnitine for treating fragile X syndrome.The Cochrane database of systematic reviews · 2015Pooled it
- Folic acid for fragile X syndrome.The Cochrane database of systematic reviews · 2011Pooled it
- Telehealth-enabled behavioral treatment for problem behaviors in boys with fragile X syndrome: a randomized controlled trial.Journal of neurodevelopmental disorders · 2020Trial
- Telehealth Delivery of Function-Based Behavioral Treatment for Problem Behaviors Exhibited by Boys with Fragile X Syndrome.Journal of autism and developmental disorders · 2019Trial
- Distance delivery of a spoken language intervention for school-aged and adolescent boys with fragile X syndrome.Developmental neurorehabilitation · 2018Trial
- Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome.Psychoneuroendocrinology · 2012Trial
- Changes in Child Behaviour Following a Brief Parenting Intervention (Triple P) for Families of Children with Phenylketonuria (PKU): A Case Series.Behavior modification · 2026Article
- Examining Phenotypic Differences in Gaze Avoidance Between Autism Spectrum Disorder and Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2022Article
- Examining the Specificity of Forms and Functions of Aggressive Behavior in Boys With Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2020Article
- Exploring the Potential of Small Molecule-Based Therapeutic Approaches for Targeting Trinucleotide Repeat Disorders.Molecular neurobiology · 2020Review
- Social Avoidance Emerges in Infancy and Persists into Adulthood in Fragile X Syndrome.Journal of autism and developmental disorders · 2019Article
- Extending the Parent-Delivered Early Start Denver Model to Young Children with Fragile X Syndrome.Journal of autism and developmental disorders · 2019Article
- Enriched Environments as a Potential Treatment for Developmental Disorders: A Critical Assessment.Frontiers in psychology · 2019Review
- A Description of the Educational Setting Among Individuals With Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2019Article
- Examining the influence of social-environmental variables on self-injurious behaviour in adolescent boys with fragile X syndrome.Journal of intellectual disability research : JIDR · 2018Article
- Problem behaviour in adolescent boys with fragile X syndrome: relative prevalence, frequency and severity.Journal of intellectual disability research : JIDR · 2016Article
- The relationship between autistic symptomatology and independent living skills in adolescents and young adults with fragile X syndrome.Journal of autism and developmental disorders · 2015Article
- Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders.Brain research · 2014Review
- Identifying large-scale brain networks in fragile X syndrome.JAMA psychiatry · 2013Article
- Biobehavioral indicators of social fear in young children with fragile X syndrome.American journal on intellectual and developmental disabilities · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Research into the determinants and developmental course of fragile X syndrome (FXS) has made remarkable progress over the last 25 years. However, treatments to ameliorate the symptoms of FXS have been less forthcoming. While there is optimism in the field that the pace of intervention research is quickening, there has been a bias toward psychopharmacological approaches to treatment. A closer look at the data from those investigations reveals a paucity of evidence that medications can improve intellectual and adaptive functioning in FXS, or decrease associated behavioral and/or emotional issues. Work in other related disorders (e.g., autism) has shown that dramatic improvements in intellectual and adaptive functioning, as well as behavioral and emotional problems, can occur if intensive behavioral treatment is begun early in the child's life. It is hoped that future research efforts will evaluate these intensive early intervention strategies in children with FXS, perhaps in combination with pharmacological approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.