ArticleAmerican journal of medical genetics. Part A2010
The process of deciding about prophylactic surgery for breast and ovarian cancer: Patient questions, uncertainties, and communication.
Article in American journal of medical genetics. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk-reducing mastectomy for the prevention of primary breast cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Genetic tests to identify risk for breast cancer.Seminars in oncology nursing · 2015Pooled it
- Patient Journey for Triple-Negative Breast Cancer: Optimal Care Pathways vs. Reality of Care in Italian Breast Units.Current oncology (Toronto, Ont.) · 2026Article
- Information needs of Lynch syndrome and BRCA 1/2 mutation carriers considering risk-reducing gynecological surgery: a qualitative study of the decision-making process.Hereditary cancer in clinical practice · 2024Article
- The Psychosocial Impact of the Decision to Undergo Risk-Reducing Salpingo-Oophorectomy Surgery inCurrent oncology (Toronto, Ont.) · 2023Review
- Racial differences in prevention decision making among U.S. women at high risk of breast cancer: A qualitative study.PloS one · 2023Article
- Professional expectations and patient expectations concerning the development of Artificial Intelligence (AI) for the early diagnosis of Pulmonary Hypertension (PH).Journal of responsible technology · 2022Article
- The ticking time-bomb. Health literacy in the context of genetic risk prediction in familial breast-ovarian cancer; A qualitative study.Qualitative research in medicine & healthcare · 2021Article
- Using patient perspectives to inform communication training materials for health care professionals discussing BRCA mutation testing.Breast cancer research and treatment · 2020Article
- Article
- Illustrating Cancer Risk: Patient Risk Communication Preferences and Interest regarding a Novel BRCA1/2 Genetic Risk Modifier Test.Public health genomics · 2020Article
- Using the Health Belief Model to explore why women decide for or against the removal of their ovaries to reduce their risk of developing cancer.BMC women's health · 2018Article
- Adaptation of couples living with a high risk of breast/ovarian cancer and the association with risk-reducing surgery.Familial cancer · 2018Article
- Involvement and Influence of Healthcare Providers, Family Members, and Other Mutation Carriers in the Cancer Risk Management Decision-Making Process of BRCA1 and BRCA2 Mutation Carriers.Journal of genetic counseling · 2018Article
- Decision making for breast cancer prevention among women at elevated risk.Breast cancer research : BCR · 2017Review
- Anxiety and depression symptoms among women attending group-based patient education courses for hereditary breast and ovarian cancer.Hereditary cancer in clinical practice · 2017Article
- Physician trust moderates the relationship between intolerance of uncertainty and cancer worry interference among women with Lynch syndrome.Journal of behavioral medicine · 2016Article
- US IRBs confronting research in the developing world.Developing world bioethics · 2012Article
- One step at a time: self-management and transitions among women with ovarian cancer.Oncology nursing forum · 2012Article
- How local IRBs view central IRBs in the US.BMC medical ethics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Many, women who have, or are at risk for, BRCA, 1/2 mutations or breast cancer decline prophylactic surgery, but questions remain as to how they make and experience these decisions. Our methods consisted of interviewing 32 women for 2 hr each; 19 were tested, 20 were symptomatic. Our results showed that these surgical options forced women to confront questions, involving stresses and uncertainties, regarding: implications of test results, prognoses with and without surgery, and effects of surgery (e.g., on self-image). Given these dilemmas, many women turned to doctors who then ranged in what and how they communicated about these issues, and how strongly they offered input. Some patients felt disappointed at provider non-directiveness, while others found providers too directive. Patients turned to family members and friends, who also ranged in how and what they communicated, and whether they agreed with the patient and/or each other. Many women turned to patient communities, but then had to decide how involved to be, and what information to provide or accept. These data suggest that providers and others may need to be more aware of the series of questions, involving stresses and uncertainties, that these women face, and the complex roles providers themselves may play. These data highlight needs for physicians to be able to address these issues flexibly, gauging patient preferences for information and paternalism (vs. autonomy). These data suggest areas for future research: for example, on how providers decide whether, what and how to communicate about these issues, and how these choices shape treatment decisions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.