ArticleInflammatory bowel diseases2010
Elevated IL-13Ralpha2 in intestinal epithelial cells from ulcerative colitis or colorectal cancer initiates MAPK pathway.
Article in Inflammatory bowel diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Inhibition of IL-13 and IL-13Rα2 Expression by IL-32θ in Human Monocytic Cells Requires PKCδ and STAT3 Association.International journal of molecular sciences · 2019Article
- New perspectives on the regulation of type II inflammation in asthma.F1000Research · 2017Review
- Interleukin-13 receptor α2 is associated with poor prognosis in patients with gastric cancer after gastrectomy.Oncotarget · 2016Article
- IL-13 induces the expression of 11βHSD2 in IL-13Rα2 dependent manner and promotes the malignancy of colorectal cancer.American journal of translational research · 2016Article
- Interleukin-13 affects the epithelial sodium channel in the intestine by coordinated modulation of STAT6 and p38 MAPK activity.The Journal of physiology · 2015Article
- IL-4 and IL-13 signaling in allergic airway disease.Cytokine · 2015Review
- CXCR3 Requirement for the Interleukin-13-Mediated Up-Regulation of Interleukin-13Rα2 in Pulmonary Fibroblasts.American journal of respiratory cell and molecular biology · 2015Article
- Retraction. Elevated IL-13Ra2 in Intestinal Epithelial Cells From Ulcerative Colitis or Colorectal Cancer Initiates MAPK Pathway.Inflammatory bowel diseases · 2015Article
- The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation.Journal of radiation research · 2014Article
- Therapeutic activity of an interleukin-4/interleukin-13 dual antagonist on oxazolone-induced colitis in mice.Immunology · 2014Article
- Evaluation of specific fecal protein biochips for the diagnosis of colorectal cancer.World journal of gastroenterology · 2014Article
- Fallen angels or risen apes? A tale of the intricate complexities of imbalanced immune responses in the pathogenesis and progression of immune-mediated and viral cancers.Frontiers in immunology · 2014Review
- Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms.Journal of cellular and molecular medicine · 2013Review
- IL-13 receptor α2 contributes to development of experimental allergic asthma.The Journal of allergy and clinical immunology · 2013Article
- Interleukin-13 and its receptors in colorectal cancer (Review).Biomedical reports · 2013Article
- Expression of interleukin-4 and interleukin-13 and their receptors in colorectal cancer.International journal of colorectal disease · 2012Article
- The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer.DNA and cell biology · 2012Article
- IBD: of mice and men-shedding new light on IL-13 activity in IBD.Nature reviews. Gastroenterology & hepatology · 2011Article
- RETRACTED: REDOX regulation of IL-13 signaling in intestinal epithelial cells: usage of alternate pathways mediates distinct gene expression patterns.Cellular signalling · 2010Article
Corrections and comments
- Retraction · 2015-07-01Concerns/Issues about Data · Concerns/Issues about Image · Investigation by Company/Institution ·
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic inflammation in ulcerative colitis (UC) is a sizeable risk factor for colorectal cancer (CRC). Interleukin-13 (IL-13) is elevated in the UC mucosa and may induce dysregulated signaling in neighboring intestinal epithelial cells (IECs) and thus function as a tumorogenic cytokine.
methodsExpression of IL-13 receptor chains on IECs obtained from control or chronically inflamed mucosa and colonic tumors was quantified by flow cytometry and immunoblot. IL-13Ralpha1 and IL-13Ralpha2 expression was significantly increased on IEC from UC and CRC patients compared to control and Crohn's disease (CD) subjects. Purified IEC from these subjects and cell lines expressing varying ratios of IL-13Ralpha1 and IL-13Ralpha2 chains were stimulated with IL-13 in vitro to investigate by immunoblot the activation of the signal transducer and activator of transcription 6 (STAT6) and mitogen activated protein kinase (MAPK) signaling pathways.
resultsDespite similarly elevated receptor expression in UC and CRC, IL-13 does not activate the STAT6 or MAPK pathways in UC, while in colonic tumors only the STAT6 pathway is activated. Using neutralizing antibodies and cell lines expressing a range of surface densities for IL-13Ralpha1 and IL-3Ralpha2, we demonstrate that IL-13Ralpha2 serves a dual role, initiating MAPK signaling at low concentrations and as an inhibitory, decoy receptor at high IL-13Ralpha2 to IL-13Ralpha1 ratios.
conclusionsIL-13Ralpha2 is both a decoy receptor and induces MAPK signal transduction, depending on its relative expression and the local concentration of IL-13, which together modulate the balance and intensity of the signaling pathways initiated in UC and CRC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.