ArticleProteomics2010
Mesoporous silica chips for selective enrichment and stabilization of low molecular weight proteome.
Article in Proteomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Pioneering Advances and Innovative Applications of Mesoporous Carriers for Mitochondria-Targeted Therapeutics.British journal of biomedical science · 2024Review
- Article
- Miniprep assisted proteomics (MAP) for rapid proteomics sample preparation.Analytical methods : advancing methods and applications · 2023Article
- Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy.Pharmaceutics · 2020Review
- Applications of Mass Spectrometry for Clinical Diagnostics: The Influence of Turnaround Time.Analytical chemistry · 2020Review
- Cathepsin B Dependent Cleavage Product of Serum Amyloid A1 Identifies Patients with Chemotherapy-Related Cardiotoxicity.ACS pharmacology & translational science · 2019Article
- Mesoporous Silica Nanomaterials: Versatile Nanocarriers for Cancer Theranostics and Drug and Gene Delivery.Pharmaceutics · 2019Review
- Understanding the Pathological Basis of Neurological Diseases Through Diagnostic Platforms Based on Innovations in Biomedical Engineering: New Concepts and Theranostics Perspectives.Medicines (Basel, Switzerland) · 2018Article
- Silk-based blood stabilization for diagnostics.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Mesoporous silica chip: enabled peptide profiling as an effective platform for controlling bio-sample quality and optimizing handling procedure.Clinical proteomics · 2016Article
- Mesoporous-silica nanofluidic channels for quick enrichment/extraction of trace pesticide molecules.Scientific reports · 2015Article
- Absolute quantification of DcR3 and GDF15 from human serum by LC-ESI MS.Journal of cellular and molecular medicine · 2015Article
- Convergence of nanotechnology and cancer prevention: are we there yet?Cancer prevention research (Philadelphia, Pa.) · 2014Review
- Antibody-free detection of Mycobacterium tuberculosis antigen using customized nanotraps.Analytical chemistry · 2014Article
- Circulating proteolytic products of carboxypeptidase N for early detection of breast cancer.Clinical chemistry · 2014Article
- Nanotechnologies in glycoproteomics.Clinical proteomics · 2014Review
- Establishment of a Strategy for the Discovery and Verification of Low-Abundance Biomarker Peptides in Plasma Using Two Types of Stable-Isotope Tags.Mass spectrometry (Tokyo, Japan) · 2014Article
- Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay.Cancer letters · 2013Article
- Monitoring the progression of metastatic breast cancer on nanoporous silica chips.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2012Article
- Low molecular weight protein enrichment on mesoporous silica thin films for biomarker discovery.Journal of visualized experiments : JoVE · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The advanced properties of mesoporous silica have been demonstrated in applications, which include chemical sensing, filtration, catalysis, drug delivery and selective biomolecular uptake. These properties depend on the architectural, physical and chemical properties of the material, which in turn are determined by the processing parameters in evaporation-induced self-assembly. In this study, we introduce a combinatorial approach for the removal of the high molecular weight proteins and for the specific isolation and enrichment of low molecular weight species. This approach is based on mesoporous silica chips able to fractionate, selectively harvest and protect from enzymatic degradation, peptides and proteins present in complex human biological fluids. We present the characterization of the harvesting properties of a wide range of mesoporous chips using a library of peptides and proteins standard and their selectivity on the recovery of serum peptidome. Using MALDI-TOF-MS, we established the correlation between the harvesting specificity and the physicochemical properties of mesoporous silica surfaces. The introduction of this mesoporous material with fine controlled properties will provide a powerful platform for proteomics application offering a rapid and efficient methodology for low molecular weight biomarker discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.