ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2010
Domain-wide regulation of DNA replication timing during mammalian development.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- ResNet-Powered Multi-Class Identification of Sequence Patterns for Genome Replication Timing Analysis.Interdisciplinary sciences, computational life sciences · 2026Article
- Replication timing uncovers a two-compartment nuclear architecture of interphase euchromatin.The Plant cell · 2026Article
- Single cell multiomics approach to analyze replication timing and gene expression in mouse preimplantation embryos.Communications biology · 2025Article
- Modeling the Dynamics of Eukaryotic DNA Synthesis in Remembrance of Tunde Ogunnaike.Industrial & engineering chemistry research · 2023Article
- A novel, rapid and sensitive flow cytometry method reveals degradation of promoter proximal paused RNAPII in the presence and absence of UV.Nucleic acids research · 2022Article
- High-throughput analysis of single human cells reveals the complex nature of DNA replication timing control.Nature communications · 2022Article
- Transcription-Replication Collisions-A Series of Unfortunate Events.Biomolecules · 2021Review
- Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing.International journal of molecular sciences · 2021Article
- Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle.Scientific reports · 2021Article
- Developmental differences in genome replication program and origin activation.Nucleic acids research · 2020Article
- Replication timing alterations in leukemia affect clinically relevant chromosome domains.Blood advances · 2019Article
- Linking the organization of DNA replication with genome maintenance.Current genetics · 2019Review
- Insights into the Link between the Organization of DNA Replication and the Mutational Landscape.Genes · 2019Review
- Regulation of the program of DNA replication by CDK: new findings and perspectives.Current genetics · 2019Review
- Genome-wide analysis of replication timing by next-generation sequencing with E/L Repli-seq.Nature protocols · 2018Article
- CDK activity provides temporal and quantitative cues for organizing genome duplication.PLoS genetics · 2018Article
- Recent advances in understanding DNA replication: cell type-specific adaptation of the DNA replication program.F1000Research · 2018Review
- Spatio-temporal re-organization of replication foci accompanies replication domain consolidation during human pluripotent stem cell lineage specification.Cell cycle (Georgetown, Tex.) · 2016Article
- BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation.The EMBO journal · 2016Article
- ASAR15, A cis-acting locus that controls chromosome-wide replication timing and stability of human chromosome 15.PLoS genetics · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Studies of replication timing provide a handle into previously impenetrable higher-order levels of chromosome organization and their plasticity during development. Although mechanisms regulating replication timing are not clear, novel genome-wide studies provide a thorough survey of the extent to which replication timing is regulated during most of the early cell fate transitions in mammals, revealing coordinated changes of a defined set of 400-800 kb chromosomal segments that involve at least half the genome. Furthermore, changes in replication time are linked to changes in sub-nuclear organization and domain-wide transcriptional potential, and tissue-specific replication timing profiles are conserved from mouse to human, suggesting that the program has developmental significance. Hence, these studies have provided a solid foundation for linking megabase level chromosome structure to function, and suggest a central role for replication in domain-level genome organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.