ArticleJournal of neuro-oncology2010
Angiogenesis and expression of estrogen and progesterone receptors as predictive factors for recurrence of meningioma.
Article in Journal of neuro-oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Meningioma enlargement associated with luteinizing hormone-releasing hormone agonist therapy: two cases and supporting in vitro evidence.Brain tumor pathology · 2026Article
- Dexamethasone Suppresses Already Low Estrogen Receptor Levels in Meningiomas.International journal of molecular sciences · 2026Review
- Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Article
- The Association Between Medroxyprogesterone Acetate Exposure and Cerebral Meningioma Among a Medicaid Population.Epidemiologia (Basel, Switzerland) · 2025Article
- Bibliometric analysis of publication trends in meningioma research (1992 - 2023).Neurosurgical review · 2025Review
- A Matched Case-Control Study Examining the Association Between Exposure to Depot Medroxyprogesterone Acetate and Cerebral Meningioma Using an Active Comparator.Current oncology (Toronto, Ont.) · 2025Article
- ADC histogram analysis of tumor-infiltrating CD8+ T cell levels in meningioma.Neurosurgical review · 2025Article
- Peritumoral vessel characteristics on magnetic resonance venography reflect the sinus invasion status of para-sinus meningioma.Quantitative imaging in medicine and surgery · 2024Article
- Article
- A nomogram to predict cancer-specific mortality in adult patients with malignant meningioma: a competing risk analysis.Discover oncology · 2024Article
- Lifestyle and metabolic factors affect risk for meningioma in women: a prospective population-based study (The Cohort of Norway).Frontiers in oncology · 2024Article
- Review
- Preoperative surgical risk assessment of meningiomas: a narrative review based on MRI radiomics.Neurosurgical review · 2022Review
- Clinical features, radiological findings, and prognostic factors for primary intracranial chordoid meningioma.Frontiers in neurology · 2022Article
- Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications.Frontiers in oncology · 2021Article
- Article
- Anaplastic meningioma seeding of the abdominal wall following calvarial bone flap preservation.Radiology case reports · 2020Article
- Recurrence/Regrowth in Grade I Meningioma: How to Predict?Frontiers in oncology · 2020Article
- Relationships Between Neurofibromatosis-2, Progesterone Receptor Expression, the Use of Exogenous Progesterone, and Risk of Orbitocranial Meningioma in Females.Frontiers in oncology · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meningiomas are benign tumors, with low rate of recurrence after surgery. The most important factor predicting recurrence is the extent of surgical resection; other factors have been studied with conflicting results. Angiogenesis, an important substratum for growth and spread of neoplasic cells, and the expression of estrogen and progesterone receptors (ER, PR), could play a role in the recurrence of meningioma. We evaluated 42 patients with meningioma diagnosis (confirmed by histopathology) treated exclusively by surgery between January 1995 and December 1999, and compared the recurring and non-recurring groups after a ten-year follow-up period. Recurrence was associated with several factors including vascular density (VD), cell proliferation index (CPI), ER, PR, and cyclin E (CE) tissue expression, as evaluated by immunohistochemistry. Complete surgical resection was achieved in 41% of patients. Recurrence of meningioma was found in 17 patients (40%). Median + or - standard deviation (SD) of recurrence time was 32 + or - 5 months. When recurrence versus no recurrence was compared, mean + or - SD of VD and CPI were 9 + or - 3.6 and 607.6 + or - 233 (40x/10 fields) respectively. Tissue expression was positive for ER, PR, and CE in 28, 62 and 91% of patients, respectively. The sole significant recurrence-associated factors were extent of resection (P = 0.003) and VD (P = 0.004). ER, PR, and CE-tissue expression were not statistically significant. The most important factor associated with meningioma relapse was vascular density, independently of hormonal status and extent of surgical resection. Patients with a high risk of recurrence could benefit from additional treatment.
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